Organizing co mmittee

 
 

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Poster presentation 
281 
QUANTUM-CHEMICAL ANALYSIS AND SYNTHESIS OF THE 
COORDINATION COMPOUND OF SODIUM M-
CRESOXYACETATE WITH COPPER (II) FORMAT 
 
M. Yakhshmuratov
2
, Sh. Khasanov
1
, Z. Abdullaeva
2
,
R. Jumanazarova
2
, M. Sabirova
 
1) Ma'mun Academy, Khiva, 
e-mail: [e-mail]
 
2) Urganch State University, Urganch 
Currently, the study of the mechanism of action of drugs on the human body is one 
of the urgent problems of medical chemistry and pharmacology. The use of modern 
innovative technologies plays an important role in creating effective tools. It is known 
from the literature that cresoxyacetate and its derivatives have been found to have 
immunomodulators, reduction of microbes in the body, hepatoprotection and many 
other biological activities [1]. 
When determining the spatial structure and coordination number of the central atom 
in the coordination compound [Cu(HCO
2
)
2 
∙ 4NaC
9
H
9
O
3
], an input file was created 
using the nonempirical method of the HyperChem 8.07 software in the MINIMAL 
STO-3G approximation, and optimization was performed in the nonempirical 3-21G 
B3LYP approximation in the Gaussian 9.0 program [2]. Four variants of the possible 
coordination structure of cobalt formate and lead(II) acetate with coordination numbers 
4 and 6 in a 1:1 ratio and coordination numbers 6 and 8 in a 1:2 ratio were considered. 
The stability of the complex compounds was analyzed based on the minimum heat of 
formation. Thus, it was found that the cobalt coordination number equal to 6 in the 
complex compound, obtained in a 1:2 ratio of salts, is stable. 
The synthesis of the complex compound was carried out according to the following 
method: 0.01 mol cobalt (II) formate was dissolved in 15 ml of water. In another 
beaker, 0.04 mol sodium methacreoxyacetate was dissolved in 20 ml of a 1:1 mixture of 
water: acetonitrile by heating in a hot water bath (at a temperature of 50-55°C). Then 
Cu (II) formate dropwise over the solution, noof a hot solution of metha-creoxyacetate 
was added and the mixture was evaporated for 4 h until the volume was reduced by a 
factor of 1.5. The resulting solution was left for 2 days. The resulting powdery 
substance was dissolved in a mixture of 2 ml of distilled water and 2 ml of alcohol and 
left for 72 hours to recrystallize..The yield of the mass of the obtained substance 
compared to the mass of the initial substance was 76.8%. 
References:
1.
Kuznetsov 
I.A., 
Voronkov 
M.G., 
Rasulov 
M.M., 
Nurbekov 
M.K. 
Immunomodulating action of tris-2(oxyethyl) ammonium cresoxyacetate and its 
mechanism // Nauchnyi elektronnyi arxiv.URL:http://econf.rae.ru/article/6916 
2.
Sh.A.Kadirova, Z.Sh.Abdullaeva, Sh.B. Khasanov. Heterometallic complex 
formate nickel (II) with zinc acetate // Universum: Chemistry and biology: electron. 
nauchn. Journal. – 2021. – No. 8(86). - C. 46-49.