Organizing co mmittee

 
 
 
 
 
 
 
 

---

Oral presentation
33 
DEVELOPMENT OF HIGHLY EFFICIENT KAZAKHSTAN’S 
HERBAL MEDICINAL SUBSTANCES WITH ANTIVIRAL 
ACTIVITY AGAINST COVID-19 AND SIMILAR VIRAL 
INFECTION 
 
A.F. Miftakhova
1,2
, M.Zh. Zhurinov
1
, A.Z.Abilmagzhanov
1
, E.T.Talgatov
1 
 
1
 D.V. Sokolsky Institute of Fuel, Catalysis and Electrochemistry 142, Kunaev 
str., Almaty, 050000, Kazakhstan 
2
 al-Farabi Kazakh National University 71 al-Farabi ave., Almaty, 050040, 
Republic of Kazakhstan 
 
Subjects of research: medicinal plants (levant wormwood Artemisia cina Berg., 
annual wormwood Artemisia annua L., Jungar iris Iris songarica, lemon balm Melissa 
officinalis L., celandine large Chelidonium majus and licorice Glycyrrhiza glabra), 
santonin, strain hCoV-19/Kazakhstan/26562/2020 of coronavirus SARS-CoV-2, strain 
A/Puerto Rico/8/34(H1N1) of influenza virus, cell cultures Vero E6 and MDCK, 
laboratory animals. 
The aim of the research is to develop highly effective drugs based on 
pharmacologically active substances from plant material with antiviral activity against 
COVID-19 and similar viral infections. 
Research methods: WHO Guidelines for Good Agricultural and Collection Practice 
(GACP) for Medicinal Plants, ultrasound and CO
2
extraction, FTIR spectroscopy, 
chromatography (TLC, HPLC, GC-MS), cyclic voltammetry, virology and 
pharmacology methods (antiviral activity and toxicity studies, molecular genetic 
analysis).
Results and novelty: Optimum conditions of PAS (physiologically active substance) 
extraction from vegetative raw material have been determined. The analysis of extracts 
and their fractions by spectroscopic and chromatographic methods. New methods for 
the extraction of santhonine and ammonium glycyrrhizinate from plant material have 
been developed. The electrochemical activity of santonine has been studied. New 
derivatives of santonin by electrochemical modification, including with high antiviral 
activity have been synthesized. 
For the first time in Kazakhstan, a successful screening of substances with activity 
against SARS-CoV-2 and influenza virus was carried out. Main constructive and 
technical-economical parameters: the studied extracts are promising as sources of drugs 
for the treatment of SARS-CoV-2 infection and influenza. The results obtained are 
patentable and can contribute to the creation in Kazakhstan of pharmacological 
production of drugs against the coronavirus disease COVID-19 and influenza. Of all the 
substances, the extracts of licorice, celandine, and the product of electrochemical 
modification (methoxylation) of santonin are of the greatest interest for further research. 
Implementation into practice is planned for the next stages. Development efficiency is 
determined by the novelty of technology in Kazakhstan.