Organizing co mmittee

 
 

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Poster presentation 
45 
TECHNOLOGY FOR OBTAINING CELLULOSE FROM SEED 
HUSKS AND MILKY JUICE OF FERULA FERULA ASSA-
FOETIDA L. 
 
Z.Kh. Sandybaeva, M.M. Murodov, N.F. Yusupova 
 
Osh State University, Osh city, Republic of Kyrgyzstan e-mail: 
[e-mail] , tel. [phone]. 
 
Introduction. It is known that about 50% of the medicines produced at 
pharmaceutical enterprises around the world are prepared from the raw materials of 
medicinal plants. Microcrystalline cellulose is used in the pharmaceutical industry as a 
binder and carrier in the production of tableted medicines. 
Purpose: Technology for obtaining cellulose from seed husks and milky juice of 
Ferula Ferula assa-foetida L for the pharmaceutical industry. 
Description: MCC is usually obtained by hydrolysis of cotton or wood pulp with 
nitric acid, with or without pressure. During hydrolysis, cellulose decomposes into 
small fractions and the bond between crystals decreases, while the degree of 
crystallinity itself increases sharply. When processing ferula seed husks, due to their 
fibrous and porous structure, heat and mass transfer processes in the volume of raw 
materials are difficult. To obtain MCC, seed husk, after preliminary extraction of 
tannins from it, is treated with an aqueous solution of nitric acid when heated. As a 
result of this treatment, part of the insoluble substances of the husk becomes water-
soluble, and the rest is easily removed during subsequent alkaline cooking in an open 
vessel. In this case, a gray mass is obtained, consisting of cotton fiber ( delint), as well 
as from the cellulose residue of the husk itself. If it is necessary to obtain separately the 
cellulose of the husk itself, the mass before or after bleaching can be subjected to light 
grinding (grinding), after which the short fibers of the husk of the ferula seeds can be 
separated by washing on a sieve. 10 g of seed husks are poured with a 3% HNO3 
solution and heated for some time until the dark beige natural color of the husk changes 
into a uniformly light beige. The temperature and time are selected depending on the 
type of the husk itself and on the requirements for the final product - cellulose. For the 
available sample, good results were achieved by treatment with 3% HNO3 At - 10 
minutes 90°, 80-20 minutes, 60-65° - 1 hour. 
One of the main uses of MCC is the pharmaceutical industry. The main requirements 
for this type of MCC include the need to comply with standards for whiteness, 
humidity, ash content and the content of water-soluble components. To ensure 
conditions for direct pressing, the product must also have good flowability, which is 
largely determined by the shape and granulometric composition of the particles; 
therefore, MCC is produced not only in the form of a fine powder, but also in the form 
of fine granules with a particle size of 80–250 μm. 
Conclusion. From the above material it can be seen that the production of 
microcrystalline cellulose from ferula seed husks is of great economic interest as a non-
waste raw material and a quality product for the pharmaceutical industry. 

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Poster presentation 
46