Organizing co mmittee

NEW COUMARINS OF WILD AND CULTIVATED APIACEAE 
PLANTS OF SIBERIA
Daniil N. Olennikov
1
, Nina I. Kashchenko
1
, Nadezhda K. Chirikova
2
1 
Institute of General and Experimental Biology, Siberian Division, Russian Academy 
of Science, 6 Sakhyanovoy Street, 670047 Ulan-Ude, Russia; 
2 
Institute of Natural 
Sciences, North-Eastern Federal University, 58 Belinsky Street, 677027, Yakutsk, 
Russia
Plants of 
Apiaceae
family are widely distributed in a Siberian flora and are the 
subject of a constant interest within the scientific community as a source of new and 
effective bioactive metabolites. As a part of ongoing studies of phenolics produced by 
Apiaceous plants [1–3], we discovered some new coumarins and investigated their 
biopotential. In particular, four new angular pyranocoumarins phlojosibirinins I–IV 
were isolated from the roots of 
Phlojodicarpus sibiricus
(Fisch.) Koso-Pol. of Baikal 
origin and identified as (+)-
cis
-khellactone di-
O
-esters with fragments of isobutyric, 
isovaleric, angelic, and senecic acids. The leaves of the plant were the source of new 
non-acylated and acylated (+)-
cis
-khellactone 
O
-glycosides (phlojosibirisides IV–VII) 
with moieties of galactose and glucose. Two new umbelliferone and scopoletin 
monoacetylated 6′-
O
-apioglucosides (villosides I and II) characterized in herb of 
Phlojodicarpus villosus
(Turcz. ex Fisch. & C.A.Mey.) Turcz. ex Ledeb collected in 
Sakha (Yakutia) Republic. Vaginidiol di-esters (ferulopsins A–C) and new vaginidiol-
1′-
O
-galactoside were found in roots of 
Ferulopsis hystrix
(Bunge) Pimenov collected 
in Chita region. The plants of 
Levisticum officinale
W.D.J.Koch cultivated in Siberian 
farming demonstrated a high level of apterin [3] and new derivatives including apterin-
O
-glycosides in roots and hydroxycinnmate-acylated apterins in herb (levistisides A–
D). Bioactivity studies demonstrated antioxidant, cytotoxic, anticholinesterase-
inhibiting and antibacterial potential of new compounds making wild and cultivated 
plants of Siberia promising sources of new pharmacological agents.
phlojosibirinin 
II