Organizing co mmittee

COMPONENTS OF THE AERIAL PART OF 
Scutellaria oxystegia 
M. T. Muradov
1
, A.R. Khurramov
2
, Kh. M. Bobakulov
2
,
A. M. Karimov
1
, E. Kh. Botirov
2
 
1
) Namangan State University, 
Namangan, Uzbekistan 
2) S.Yu.Yunusov Institute of the Chemistry of Plant Substance, Academy of Science of 
the Republic of Uzbekistan, 
e-mail: [e-mail] 
Plants of the genus 
Scutellaria
(family 
Lamiaceae
) are presented by approximately 
360-469 species on the globe are widely distributed in temperate, subtropical, and 
tropical regions, including Europe, North America, and East Asia [1]. There are 38 
species of 
Scutellaria
on the territory of Uzbekistan, some of which are used in folk 
medicine to treat epilepsy, allergies, neurosis, hypertension, and other diseases.
Continuing the systematic study of the chemical components of plants of this genus, 
we studied the chemical composition of phenolic compounds of the above-ground part 
of 
S. oxystegia
collected on the territory of Tashkent region (Kamchik pass) of the 
Republic of Uzbekistan during flowering (May, 2021). Three flavonoids were isolated 
earlier from this species and the component composition of the essential oil of the 
aboveground part was studied. 
By chromatography on columns with silica gel and Sephadex LH-20, the flavonoids 
chrysin, luteolin, cynaroside, phytosterols β -sitosterol, daucosterol, and iridoid latifonin 
were isolated from a 70% ethanol extract of air-dried, crushed above-ground parts of the 
plant.
Identification of the isolated compounds was performed by studying their spectral 
data from UV, 
1
H and 
13
C NMR, as well as HSQC and HMBC experiments, followed 
by comparison with literature data for the corresponding compounds. 
Fig.1. Chemical and spatial structure of the latifonin molecule 
The configuration (4
R
,5
S
,6
S
,7
S
,8
R
,9
S
) and structure - methyl(4
R
,5
S
,6
S
,7
S
,8
R
,9
S
)-
6,7,8-trihydroxy-8-methyl-1-oxoоctahydrocyclopenta[
c
]-pyran-4-carboxylate 
were 
established based on X-ray diffraction analysis results for latiphonine. 
References 
1. M. Shah, S. Mubin, S. Shams ul Hassan, P. Tagde, O. Ullah, Md. Habibur 
Rahman, A. Al-Harrasi, N. UrRehman, W. Murad. 
Phytochemical Profiling and Bio-
Potentiality of Genus 
Scutellaria
: Biomedical Approach. 
Biomolecules,
2022. V. 12.
 
P. 
936.
O
O
H
H
HO
HO
HO
O
O
Me
1
3
4
5
6
7
8
9
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Poster presentation 
90