Organizing co mmittee

part of Türkiye and in Arab countries, while date kernels have been used for a 
traditional date kernel herbal coffee (Café de noyaux de dattes) in the northern Africa. 
Moreover, a novel herbal coffee has been produced by Sekeroglu and Gezici from olive 
kernels, which are mainly used as a source of heating energy by burning. In the folk 
medicine, olive kernels are being swallowed for their gastrointestinal disorders and 
other health benefits in the southeastern part of Türkiye. Olive kernel coffee contains 
some medicinal plants and spices that have a good non-caffeine healthy functional 
beverage. In addition to their traditional uses, many plant residues as natural sustainable 
byproducts are waiting to be rediscovered for human welfare and zero waste in fighting 
the climate crisis on the worldwide.

---

Plenary presentation
9 
ON THE PHARMACOLOGICAL ACTIVITY AND PROSPECTS FOR THE 
PRACTICAL USE OF 1-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES 
 
F.M.Tursunkhodjaeva, A.A.Azamatov, Sh.N.Zhurakulov, V.I.Vinogradova 
 
Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of 
Uzbekistan, Tashkent, [e-mail] 
The 1,2,3,4-tetrahydroisoquinoline (THIQ) derivatives have been reported to 
possess a wide range of pharmacological activities like anti-inflammatory, anti-
bacterial, anti-viral, anti-fungal, anti-leishmanial, anti-cancer, anti-malarial, anti-
Alzheimer, 
antiparkinsonian, 
antidepressant, 
anticonvulsant, 
antiarrhythmic, 
hypotensive and hypertensive, and inhibiting NO production. Some of the THIQ 
analogs are used clinically: Praziquantel (antihelmintic), Quinapril (antihypertensive), 
Apomorphine (Antiparkinsonian), Tubocurarine (skeletal muscle relaxant), Trabectedin 
(anticancer) and others. 
We have investigated 1-aryl-1,2.3.4-THIQ derivatives synthesized at the 
Institute of the Chemistry of Plant Substances, Uzbekistan. Among 32 studied 
substances we have identified potent substances with local-anesthetic, analgesic, anti-
inflammatory, 
antiarrhythmic, 
antihypoxic, 
psychotropic, 
antioxidant 
and 
anticonvulsant activity. 
Structure-toxicity and structure-activity relations were analyzed.