Research results.
After modeling atherosclerosis in the blood of rabbits, there was a
significant increase in the level of CL from 3.97 ± 0.07 to 12.2 ± 2.3 mmol/l (p <0.01),
TG from 1.38 ± 0.1 to 6 .95 ± 1.1 mmol/l (p <0.005), LDL fractions from 2.4 ± 0.1 to
6.76 ± 0.8 mmol/l (p <0.003), an insignificant increase in the level of HDL fractions
with 0.98 ± 0.03 to 1.41 ± 0.2 mmol/l, at p ≤ 0.1.
After treatment of animals with atherosclerosis with L-arginine in
the blood serum,
there was a decrease in the level of CL from 12.2 ± 2.3 to 5.28 ± 0.4 mmol/l (p <0.03),
TG from 6.9 5 ± 1 .1 to 0.83 ± 0.06 mmol/l (p <0.003), LDL from 6.76 ± 0.8 to 3.29 ±
0.2 mmol/l (p <0.008), a decrease in the level was also noted HDL from 1.41 ± 0.2 to
0.9 ± 0.06 mmol/l (p<0.08).
Conclusions.
As the
results of our study showed, experimental
atherosclerosis was
accompanied by a significant increase in
the level of total cholesterol,
triglycerides, high
and low density lipoproteins in the blood of animals.
As
a result of morphology,
thickening of the intima,
deposition of cholesterol, fat
cells and increased proliferation of connective tissue with the subsequent
development
of atherosclerotic plaques in the intima were revealed. After treatment with L-arginine
in rabbits, there is a decrease in cholesterol deposition, there is a tendency to reduce the
progression of atherosclerosis.
