QUINOLINE ALKALOIDS OF THE FAMILY RUTACEAE Kh.A. Rasulova, D.R. Kodirova, M.A. Eshonov, Z.Ch. Abraeva S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences, 100170, Tashkent, Uzbekistan, fax (99871) 120 64 75, e-mail: khalida.rasulova@gmail.com The pharmacological studies of quinoline alkaloids and their derivatives isolated
from plants of
Haplophyllum genus
( fam. Rutaceae), which are unique source of various
alkaloids, showed that they are low toxic and have wide spectrum of pharmacological
action. Most of them possess by inhibitory action on CNS, sedative, sleeping,
anticonvulsant, estrogen and other effects.
In the last period, alkaloids of 6 plant species of the Rutaceae family have been
studied. Alkaloids of the plants
Haplophyllum perfaratum, H.griffithianum, H.ramossimum, H.pedicellatum, H. acutifolium, Ruta graveolens, Dictamnus angustifolus were studied.
The study of 2 new plant species has begun.
The structures of the isolated new alkaloids were established on the basis of the
study of spectral datas (UV-, IR-,
1
H and
13
C-NMR, DEPT-spectra) and X-ray
diffraction data from the plants.
O
N
O
OCH
3
CH
3
H
3
C
2
3
4
10
5
6
7
8
9
11
12
13
14
15
1 A
B
C
N
O
OCH
3
OCH
3
RO
N
O
OCH
3
OCH
3
CH
2
O
H
2
C
CH
3
N
O
O
CH
3
OCH
3
HOCH
2
-CH-C-O
OH
CH
3
CH
3
N
O
H
O
O
O
5
3
N
O
H
O
1'
2'
3'
1" 2"
3"
4
5
8a
O
OMe
N
H O
C
H
2
O
N
H
O
MeO
1
3
5 6
7
8
9
10
11
1'
3'
5'
6'
7'
8'
9'
10'
