Poster presentation
263
SYNTHESIS, CRYSTAL STRUCTURE AND HIRSHFELD
SURFACE ANALYSIS OF NEW DERIVATIVE OF
THIENO[2,3-D]PYRIMIDINE
A.U. Berdiev
1
, M.O. Hakimov
2
, Ch.J. Elmuradov
3
, I.S. Ortikov
1
, K.K. Turgunov
1,4
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
2) Namangan State University, Namangan 160136, Uzbekistan
3
) Karshi State University, Karshi 180119, Uzbekistan
4) Turin Polytechnic University in Tashkent,
Tashkent 100095, Uzbekistan
Many thieno[2,3-d]pyrimidine (TP) derivatives were reported as phosphodiesterase
inhibitors, also exhibited good H
1
receptor antagonistic activities, 4-amino derivatives
showed insecticidal and acaricidal activities. Numerous TPs have been proved to use in
case of cerebral ischemia, malaria, tuberculosis, Alzheimer’s and Parkinson’s diseases.
In this context, TP containing piperidine fragment with similar structural qualities
would be projected to result in newer molecular systems with increased efficacy.
Definitely, piperidine template has been known to express considerable antimicrobial,
antitubercular and anticancer activities. A systematic approach to the synthesis of
targeted compound
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