Organizing co mmittee

2b
and 2c. Taking into account the 
dominance of the 3-methoxy derivative of echinochrome (
3
) in renal excretions, it can 
be assumed that this product has a structure of 1-((2,5,8-trihydroxy-3-methoxy-7-ethyl-
1,4-naphthoquinone-6-yl)oxy)urea (
2b
). 
The final conclusion about the structure of the detected products can be made on the 
basis of the results of counter synthesis. In addition, synthesis will make these 
compounds available, which will allow them to be biotested. Of particular interest is the 
synthesis of metabolite 
2a
. This product is notable because it is a hybrid of 
hydroxycarbamide (
4
), a cytostatic, and echinochrome (
1
), a cardioprotector, known 
vital medicines. 

---

Poster presentation 
57 
DEVELOPMENT OF A DOSAGE FORM - GEL BASED ON 
EXTRACT OF XANTHIUM STRUMARIUM L. 
 
Nazigul Serikovna Remetova, Khorlan Iskozhiyevna Itzhanova 
 
NJSC “Karaganda Medical University”, Karaganda, Republic of Kazakhstan 
Key words: Xanthium strumarium
L., extracts, gels, medicinal plant, technology. 
Of great interest for practical medicine are medicinal preparations for external use in 
the form of gels, since they have great advantages over ointments. When they are 
applied to the skin, the thinnest smooth films are formed, they are well absorbed 
through the skin, and so on. Gels are widely used in the treatment of rheumatoid 
arthritis, atopic dermatitis, in dentistry, proctology, urology and in the treatment of other 
diseases [1-3]. 
We have developed a gel for external use, the active ingredients and auxiliary 
ingredients (polyethylene glycols, microcrystalline cellulose, polyvinylpyrrolidone, 
carbopol, gelatin) have been introduced into the composition. The compositions of 5 gel 
models were selected. Biopharmaceutical parameters for the release of active 
substances by diffusion into a 2% agar solution were carried out and the optimal 
composition was determined. 
The optimal composition of the medicinal agent in the form of a gel consists of an 
extract of 
Xanthium strumarium
L. 5.0; essential oil of 
Pinus sylvestris
L. 1.0; 
chondroitin sulfate 0.1; polyethylene glycol brand 400: polyethylene glycol brand 1500 
in the ratio (95:5); purified water up to 100.0.
The indicators of the appearance and consistency of the dosage form were 
established in terms of mass uniformity, where the criterion for uniformity was the 
absence of individual visible particles of active substances, foreign impurities, as well 
as signs of coagulation, particle aggregation, phase separation. 
The developed gel is a viscous, homogeneous brown mass. Potentiometric method 
determined the pH of the water extract, which was -5.4. The rheological quality 
indicators for the dosage form - gel were established. 
Literature 
1. Alekseev K.V. Polymers in the technology of creating dosage forms with modified 
release / K.V. Alekseev, N.V. Tikhonova, E.V. Blynskaya [et al.] // Russian Chemical 
Journal. - 2010. - No. 6. - P. 87 - 93. 
2. Grikh V.V. Development of soft dosage forms containing solid dispersions / V.V. 
Grikh, I.I. Krasnyuk (Jr.), A.V. Belyatskaya [et al.] // Development and registration of 
dugs. - 2018. - No. 1. - P. 36 - 38. 
3. Pharmacopoeia of the Eurasian Economic Union (EAEU).-2020.1. P.555-565. 

---

Poster presentation 
58