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Poster presentation 
255 
EFFECT OF 33 DERIVATIVES OF 1-ARYL-6,7-DIMETHOXY-
1,2,3,4-TETRAHYDROISOQUINOLINE ON THE LOCOMOTOR 
ACTIVITY OF INTACT AND AMPHETAMINE-TREATED MICE 
IN THE OPEN FIELD 
 
A.A. Azamatov, F.M. Tursunkhodzhaeva, Sh.N. Zhurakulov, 
V.I. Vinogradova, K.K. Akhmedzhanov 
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of 
sciences of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
 
Nowadays, studies at creation of effective modulators of the neurotransmitter 
systems of the brain attract scientists’ attention. Alcohol is considered the most common 
exogenous toxin causing encephalopathy. The dopaminergic system plays a role in the 
development of various mental and movement disorders. Studies have shown that the 
preference for alcohol is accompanied by an increase in the activity of the dopaminergic 
system in the brain. In this regard, the search for agonists and antagonists of dopamine 
release can be considered an urgent task in the creation of both anti-alcohol drugs and 
drugs for the treatment of neurodegenerative diseases. We have studied the effect of 33 
derivatives of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (Structure I) on the 
locomotor activity of intact animals, as well as on the locomotor activity of 
amphetamine in the open field conditions. The test substances were administered at a 
dose of 1 mg/kg orally 1 hour before the start of the experiment. Amphetamine was 
administered at a dose of 5 mg/kg subcutaneously in one hour after the administration 
of the test substances. 
Amphetamine antagonists include substances