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Research results.
After modeling atherosclerosis in the blood of rabbits, there was a
significant increase in the level of CL from 3.97 ± 0.07 to 12.2 ± 2.3 mmol/l (p <0.01),
TG from 1.38 ± 0.1 to 6 .95 ± 1.1 mmol/l (p <0.005), LDL fractions from 2.4 ± 0.1 to
6.76 ± 0.8 mmol/l (p <0.003), an insignificant increase in the level of HDL fractions
with 0.98 ± 0.03 to 1.41 ± 0.2 mmol/l, at p ≤ 0.1.
After treatment of animals with atherosclerosis with L-arginine in the blood serum,
there was a decrease in the level of CL from 12.2 ± 2.3 to 5.28 ± 0.4 mmol/l (p <0.03),
TG from 6.9 5 ± 1 .1 to 0.83 ± 0.06 mmol/l (p <0.003), LDL from 6.76 ± 0.8 to 3.29 ±
0.2 mmol/l (p <0.008), a decrease in the level was also noted HDL from 1.41 ± 0.2 to
0.9 ± 0.06 mmol/l (p<0.08).
Conclusions.
As the results of our study showed, experimental atherosclerosis was
accompanied by a significant increase in the level of total cholesterol, triglycerides, high
and low density lipoproteins in the blood of animals.
As a result of morphology, thickening of the intima, deposition of cholesterol, fat
cells and increased proliferation of connective tissue with the subsequent development
of atherosclerotic plaques in the intima were revealed. After treatment with L-arginine
in rabbits, there is a decrease in cholesterol deposition, there is a tendency to reduce the
progression of atherosclerosis.
Contents
International Scientific Conference on Actual Problems of the
Chemistry of Natural Compounds Dedicated to the 80
t h
Anniversary of the Academy of Sciences of the Republic of
Uzbekistan
Plenary presentations……………………………………………1 – 15
Oral presentations……………………………………………....17 – 36
Poster presentations……………………………………………37 – 343
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