INFLUENCE OF L-ARGININE ON LIPID METABOLISM IN EXPERIMENTAL ATHEROSCLEROSIS AND MORPHOLOGICAL CHARACTERISTICS OF THE MYOCARDIA IN ANIMALS Nuriza Akynbekova, Zhyldyz Makhmudova Kyrgyz State Medical Academy named after. I.K. Akhunbaeva, Bishkek, Kyrgyzstan. Department of Biochemistry with the course of general and bioorganic chemistry named after A.J. Dzhumalieva, e-mail: nuriza.akynbekova@bk.ru Relevance. On a global scale, morbidity and mortality from cardiovascular diseases
occupies a leading position among the most common non-communicable diseases,
which is also typical for Kyrgyzstan. The main cause of death among the population
from coronary heart disease is atherosclerosis. The accumulation of cholesterol in the
walls of blood vessels in the form of plaques is a violation of lipid metabolism.
Purpose of the study. The study of lipid metabolism and myocardial morphology in
rabbits before and after atherosclerosis modeling against the background of the use of
L-arginine as a donor of nitric oxide.
Materials and methods. 18 rabbits were divided into 3 groups: group 1 - intact
animals; group 2 - animals with simulated atherosclerosis (oral administration of
cholesterol at a dose of 500 mg/kg of body weight 1 time per day for 60 days); group 3 -
animals with simulated atherosclerosis on the background of the use of L-arginine (oral
administration at a dose of 170 mg/kg of body weight 1 time per day for a month). To
study the morphology of the myocardium of rabbits, micropreparations 5-6 microns
thick were made, the sections were stained with hematoxylin - eosin. A comparative
assessment of the histological picture was carried out before and after atherosclerosis
modeling, as well as after L-arginine therapy.
