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INFLUENCE OF L-ARGININE ON LIPID METABOLISM IN



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Abstracts ICPS 2023

INFLUENCE OF L-ARGININE ON LIPID METABOLISM IN 
EXPERIMENTAL ATHEROSCLEROSIS AND MORPHOLOGICAL 
CHARACTERISTICS OF THE MYOCARDIA IN ANIMALS 
 
Nuriza Akynbekova, Zhyldyz Makhmudova
Kyrgyz State Medical Academy named after. I.K. Akhunbaeva, Bishkek, Kyrgyzstan. 
Department of Biochemistry with the course of general and bioorganic chemistry 
named after A.J. Dzhumalieva, 
e-mail:
nuriza.akynbekova@bk.ru
 
 
Relevance.
On a global scale, morbidity and mortality from cardiovascular diseases 
occupies a leading position among the most common non-communicable diseases, 
which is also typical for Kyrgyzstan. The main cause of death among the population 
from coronary heart disease is atherosclerosis. The accumulation of cholesterol in the 
walls of blood vessels in the form of plaques is a violation of lipid metabolism. 
Purpose of the study.
The study of lipid metabolism and myocardial morphology in 
rabbits before and after atherosclerosis modeling against the background of the use of 
L-arginine as a donor of nitric oxide. 
Materials and methods.
18 rabbits were divided into 3 groups: group 1 - intact 
animals; group 2 - animals with simulated atherosclerosis (oral administration of 
cholesterol at a dose of 500 mg/kg of body weight 1 time per day for 60 days); group 3 - 
animals with simulated atherosclerosis on the background of the use of L-arginine (oral 
administration at a dose of 170 mg/kg of body weight 1 time per day for a month). To 
study the morphology of the myocardium of rabbits, micropreparations 5-6 microns 
thick were made, the sections were stained with hematoxylin - eosin. A comparative 
assessment of the histological picture was carried out before and after atherosclerosis 
modeling, as well as after L-arginine therapy. 

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