Organizing co mmittee

 
 

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Poster presentation 
341 
THE STATE OF LIPID METABOLISM IN OLD RATS IN HIGH 
ALTITUDE CONDITIONS AGAINST THE BACKGROUND OF 
THE USE OF COENZYME Q10 
 
Gulbarchyn Asrankulova, Zhyldyz Makhmudova
 
Kyrgyz State Medical Academy named after. I.K. Akhunbaeva, Bishkek, Kyrgyzstan. 
Department of Biochemistry with the course of general and bioorganic chemistry 
named after A.J. Dzhumalieva
. 
email: 
[e-mail]
  
 
Annotation.
It is known that in conditions of high mountains, the body is affected by 
extreme factors of high mountains, which accelerate the aging process and reduce life 
expectancy. In this regard, it becomes necessary to search for ways and methods of drug 
therapy in order to increase the duration and quality of life, since the action of many 
pharmacological drugs in a mountainous climate is manifested specifically. Coenzyme 
Q10 was used as the studied antioxidant. 
The experiments were carried out on 24 laboratory rats aged 15-18 months weighing 
300-350g in low mountains (in the Intersectoral Educational and Scientific Center for 
Biomedical Research of the Kyrgyz State Medical Academy named after I.K. 
Akhunbaev, Bishkek, 720 m above the level sea), and on the 30th day of the stay of 
animals in high mountains (Too-Ashuu pass, 3200 m above sea level).
In conditions of low mountains and on the 30th day of the stay of animals in 
conditions of high mountains, the animals were divided into the following groups: 
1 - intact group of old rats located in the low mountains. 
Group 2- is old rats that have undergone 30 days of adaptation in high altitude 
conditions. 
Group 3 - a group of old rats that received coenzyme Q10 orally at a dose of 30 
mg/kg of body weight 1 time per day for 30 days during a meal.
Conclusion.
After a 30-day adaptation of old rats in high altitude conditions, 
compared with old low mountain rats without drug treatment, there was a decrease in 
cholesterol levels from 4.24±0.24 to 2.24±0.27 mmol/l (p˂0.00) . triglycerides from 
1.18±0.12 to 0.85±0.07 mmol/l (p˂0.04), HDL fractions from 1.42±0.16 to 0.97±0.07 
mmol/l (p ˂0.03), LDL fraction from 2.92±0.29 to 1.53±0.16 mmol/l (p˂0.00).
After treatment with coenzyme Q10 in 30-day-old adapted old rats, cholesterol 
decreased from 2.24±0.27 to 1.63±0.14 mmol/l, triglycerides slightly and not 
significantly decreased from 0.85±0.07 to 0, 77 ± 0.05 mmol / l, fractions HDL 
remained almost unchanged from 0.97 ± 0.07 to 0.94 ± 0.05 mmol / l, fractions LDL 
decreased from 1.53 ± 0.16 to 1, 01±0.13 mmol/l (p˂0.03).