Poster presentation
55
SYNTHESIS OF (1S,9aR)-1-[(1,2,3-TRIAZOL-1-
YL)METHYL]OCTAHYDRO-1H-
QUINOLIZINES FROM
ALKALOID LUPININE
Z.M. Muldakhmetov, Zh.S. Nurmaganbetov, O.A. Nurkenov, S.D. Fazylov
Institute of organic synthesis and coal chemistry of the Republic of Kazakhstan,
Kazakhstan, 100008, Karaganda, str. Alikhanov, 1;
e-mail:
nzhangeldy@yandex.ru
Azide of lupinine alkaloid has been obtained from lupinine in two stages. The
reaction of lupinine
1
with methanesulfonyl chloride in the presence of Et
3
N in CH
2
Cl
2
has resulted in octahydro-2
H
-quinolizine-1-yl)methyl methanesulfonate
2
. The reaction
of octahydro-2
H
-quinolizine-1-yl)methyl methanesulfonate with NaN
3
in DMF has led
to a relevant
natural quinolizine azide
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