EVALUATION OF THE LUNG DISEASE SEVERITY IN INFANTS WITH RESPIRATORY DISTRESS
SYNDROME
AleksandrovichJu.S
1
.,Blinov S.A.
1,2
, Pshenisnov K.V.
1,2
, Parshin E.V.
1,2
1Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia; 2Leningrad Regional
Children’s Hospital, Saint-Petersburg, Russia
correspondence to: Aleksandrovich Jurij Stanislavovich
e-mail:
Jalex1963@mail.ru
Abstract:
Optimization of respiratory support and prevention of ventilator-associate lung injure are the most
important problems of neonatal resuscitation and intensive care. The aim of the study: To improve the results
of intensive care for respiratory failure in preterm infants by optimizing respiratory support on the basis of the
analysis of the biomechanical characteristics of the lungs and blood gas. Materials and Methods: The study
included 138 infants with birth weight 1500g (1300-1740g) and a gestational age of 30.5 (29-32) weeks in
need of mechanical ventilation. Apgar score at one minute was equal to 5.0 (4.0-6.0) points, and the fifth - 7.0
(6.0-7.0) points. Biomechanical properties of light investigated the dynamic lung compliance, aerodynamic
upper airway resistance, the coefficient of hyperextension, the time constant and the coefficient of RVR,
reflecting the patient’s spontaneous breathing pattern were evaluated. Results: It was found that the most
significant biomechanical characteristics of lungs, reflecting the severity of the respiratory failure are the
dynamic compliance, aerodynamic airway resistance, coefficient C20/C, and the time constant. Correlation
between the index of oxygenation, clinical assessment of the severity of respiratory failure and the duration of
control mechanical ventilation was demonstrated. Conclusion: Rate of hyperextension and time constant are
expressed by the correlation with the level of the oxygenation index, which allows them to be used for
screening evaluation of severity critically ill patients during admission to the neonatal intensive care unit.
Key words:
biomechanical characteristics of lungs, dynamic compliance, aerodynamic airway resistance,
neonate, respiratory distress syndrome, hypoxic-ischemic encephalopathy
AN-1401-058
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