K.J. Downey, Y. Wang,
K. Sun, E. Lin, Y. Wu and Q. Liu. Montefiore Med. Ctr., Bronx.
A396
645.7
Decreased SLPI levels in smokers is
associated with increased inflammation and IAV infection.
M.
Meyer, R. Bauer, L. Brighton and I. Jaspers. Univ. of North
Carolina at Chapel Hill.
A397
645.8
Human airway epithelial secretions inhibit the
formation of Pseudomonas aeruginosa biofilms.
A.W. Sorum,
A.M. Zank and J.L. Bankers-Fulbright. Augsburg Col., MN.
A398
645.9
Selective inhibition of gliadin immune
reactivity by transamidation of wheat flour with microbial
transglutaminase.
G. Iaquinto, E. Lombardi, P. Bergamo, F.
Maurano, G. Bozzella, D. Luongo, G. Mazzarella, V. Rotondi
Aufiero and M. Rossi. San G. Moscati Hosp. and Natl. Council
Res., Avellino, Italy.
A399
645.10 Early growth response-1 in the pathogenesis
of cysteamine-induced duodenal ulcer.
T. Khomenko, X.
Deng, K.N. Patel, Z. Sandor and S. Szabo. VA Med. Ctr., Long
Beach, Univ. of California, Irvine.
A400
645.11 Exploring phospho-signaling pathways in
patients with age-related macular degeneration, human
pigment epithelial cell line ARPE-19 and porcine ocular tissue.
E. Fasler-Kan, N. Barteneva and P. Meyer. Inst. of Chem. and
Bioanalyt., Muttenz, Switzerland, Immune Dis. Inst., Boston
and Univ. of Basel.
A401
645.12 Identification of endogenous pro-resolving
mechanisms in a murine model of cryptococcal pneumonia.
J.K. Colby, K. Gott, J. Wilder and B.D. Levy. Brigham and
Women’s Hosp., Harvard Med. Sch. and Lovelace Resp. Res.
Inst., Albuquerque.
646. ENDOTHELIAL-LEUKOCYTE INTERACTIONS
Poster
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A402
646.1
Endothelial calcium signaling during leukocyte
transendothelial migration.
E. Weber, F. Han and W.A. Muller.
Northwestern Univ. Feinberg Sch. of Med.
A403
646.2
The mechanism of CD99 and CD99l2
in leukocyte transendothelial migration.
R.L. Watson, A.
Mikhailov and W.A. Muller. Northwestern Univ., Chicago and
Mount Sinai Hosp., New York.
A404
646.3
Pharmacological inhibition of p38 mitogen-
activated protein kinases affects KC/CXCL1-induced
intraluminal crawling, transendothelial migration, and
chemotaxis of neutrophils in vivo.
L. Liu, M. Hossain and S.M.
Qadri. Univ. of Saskatchewan.
A405
646.4
Kinin B1 receptor regulates inflammatory cell
recruitment during low laminar shear stress.
K. Martin, M.
Perretti and A. Ahluwalia. Barts & The London Med. Sch.
A406
646.5
Pathway of leukocyte transendothelial
migration across an in vitro human blood brain barrier model.
R.C. Winger, J.E. Koblinski and W.A. Muller. Northwestern
Univ. Feinberg Sch. of Med.
A407
646.6
Kinesin-1 mediates targeted recycling of the
lateral border recycling compartment.
B. Cyrus and W. Muller.
Northwestern Univ., Chicago.
A408
646.7
Activation of polymorphonuclear cells releases
the chemotactic factor Ecrg4 into conditioned media.
T.W.
Costantini, S. Knowling, X. Dang, B.P. Eliceiri, A. Baird and
R. Coimbra. Univ. of California San Diego Hlth. Sci.
A409
646.8
Live kidney slices present a novel method for
delineating the mechanisms of calcineurin inhibitor-mediated
nephrotoxicity.
M. Kelly, C. Crawford, R-L. Loo, M. Delaney,
C. Farmer, S.S.P. Wildman and C.M. Peppiatt-Wildman.
Medway Sch. of Pharm., Univs. of Kent and Greenwich and
East Kent Hosps. Univ. NHS Fndn. Trust, Canterbury.
NUTRITION/PATHOLOGY SUNDAY
189
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A410
646.9
Urinary ATP and bacteria in shed urothelial
cells as a superior diagnostic marker for urinary tract infection
in renal transplant recipients.
S.P. Kelley, R. Birch, T.S. Scott-
Ward, C.M. Peppiatt-Wildman, C. Farmer, M. Delaney and
S.S.P. Wildman. Medway Sch. of Pharm., Univs. of Kent and
Greenwich and East Kent Hosps. Univ. NHS Fndn. Trust,
Canterbury.
A411
646.10 Matrix metalloproteinase-9 inhibition
attenuates wall thinning but increases neutrophil infiltration
post-myocardial infarction in mice.
R.P. Iyer, N.L. Patterson,
G.B. Fields and M.L. Lindsey. Univ. of Texas Hlth. Sci. Ctr. at
San Antonio, Barshop Inst. for Longevity and Aging Studies,
San Antonio and Torrey Pines Inst. for Molec. Studies, Port St.
Lucie, FL.
A412
646.11 Control of VEGF-endothelial response by
ECM stiffness.
K.E. Derricks, V. Trinkaus-Randall and M.A.
Nugent. Boston Univ. Sch. of Med.
A413
646.12 Modulating myeloperoxidase-induced
endothelial permeability by a carbon monoxide-releasing
molecule, CORM-3.
E.K. Patterson, F. Serizawa, A. Capretta,
D.D. Fraser, R.F. Potter and G. Cepinskas. Lawson Hlth. Res.
Inst., London, ON and McMaster Univ., Canada.
A414
646.13 Autocrine regulation of endothelial barrier
integrity by CAP37.
E. Fox, A. Pereira and J. Reichner. Alpert
Med. Sch. of Brown Univ./Rhode Island Hosp. and Univ. of
Oklahoma Hlth. Sci. Ctr.
647. MICROBES AND INNATE IMMUNE RESPONSE
Poster
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A415
647.1
Role of Toll-like receptor 4 in Legionella
pneumophila infection with C3H/HeJ mouse model.
W-w. Wu,
S-p. Wang, F. Zhang, X-d. Gao and J-m. Dong. Shanxi Med.
Univ., China.
A416
647.2
Polymorphisms in Toll-like receptors 2 and
5 are associated with Legionella pneumophila infection.
F.
Zhang, S-p. Wang, X-d. Gao and W-w. Wu. Sch. of Publ. Hlth.,
Shanxi Med. Univ., China.
A417
647.3
Role of innate immunity in immune enhancing
effects of Candida skin test reagent.
M. Nakagawa, H.
Coleman, J. Sikes, J. Daniels and U. Nagarajan. Univ. of
Arkansas for Med. Sci.
A418
647.4
Group B Streptococcus induces a caspase-
dependent apoptosis in fetal rat lung interstitium.
D.E. Kling,
M.P. Murphy and D.S. Newburg. Boston Col.
A419
647.5
Regulation of the osmotic tolerance response
in the halophile Vibrio parahaemolyticus.
L.A. Powell. Univ. of
Delaware.
A420
647.6
Giardia duodenalis genotype A and B are
responsible for post-infectious visceral hypersensitivity in an
immunocompetent suckling rat model: Is commensal bacterial
translocation one of the mechanisms leading to PI-IBS?
M.C.
Halliez, L. Le Goff, A. Francois, G. Gargala, L. Favennec
and A.G. Buret. Univ. of Calgary, Canada and Univ. of Rouen,
France.
A421
647.7
Giardia duodenalis cysteine cathepsin
proteases and their role in intestinal disease.
A. Bhargava, J.A.
Cotton, R. Yates and A.G. Buret. Univ. of Calgary, Canada.
A422
647.8
Characterization of Debaryomyces hansenii
strains as a potential treatment against superficial mycoses.
V.
Gordian, Y. Serrano and N. Arroyo. Pontifical Catholic Univ. of
Puerto Rico.
A423
647.9
Evaluation of macrophage migration inhibitory
factor level in sera of patients with alopecia areata.
D.A.
Younan, N. Ebeid, N. Agamia and A. El-Shafaei. Fac. of
Med., Alexandria Univ., Egypt.
A424
647.10 The structure of associated diseases in children
with alopecia areata.
Z. Dzhetpisbaeva and A. Abduldayeva.
Med. Univ. Astana, Kazakhstan.
A425
647.11 Ozonation as an anti-microbial technique in
dental treatment units.
R.B.S. Jacinto, E. Mergulhao, A.C.
Fornel, R. Navarro and R.A. Zangaro. Univ. Paulista, FATEC
and Unicastelo, São Jose dos Campos, Brazil.
A426
647.12 Histone deacetylase inhibition prevents and
restores bacterial lipopolysaccharide-induced paracellular
hyper-permeability in human lung microvascular endothelial
cells.
A.D. Joshi, G. Thangjam, N. Barabutis, M. Shaw, V.
Patel and J.D. Catravas. Georgia Hlth. Sci. Univ.
A427
647.13 Inhibition of Toll-like receptor signaling by an
ITIM-containing bacterial protein.
B. Ge. Tongji Univ., Shanghai
Pulm. Hosp., China.
648. IMMUNE MEDIATORS IN INFLAMMATION AND
AUTOIMMUNITY MODELS
Poster
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A428
648.1
Interleukin-33 drives a proinflammatory
endothelial activation that selectively targets non-quiescent
cells.
G. Haraldsen. Oslo Univ. Hosp.
A429
648.2
Analysis of ligands for CD83, a marker of
activated immune cells.
Y. Ando, T. Oku, M. Tsuiji and T. Tsuji.
Hoshi Univ., Japan.
A430
648.3
Gamma delta T-cells regulate myeloid cell
activity after injury.
M.G. Schwacha, M. Rani and Q. Zhang.
Univ. of Texas Hlth. Sci. Ctr. at San Antonio and U.S. Army Inst.
of Surg. Res., Fort Sam Houston.
A431
648.4
Interleukin-6 induced matrix
metalloproteinase-9 expression in macrophages:
cyclooxygenase-2-dependent and independent pathways.
P. Kothari, R. Pestana, R. Mesraroua, R. Elchaki and D.J.
Falcone. Weill Cornell Med. Col.
A432
648.5
Identifying mechanisms of interleukin-19-
mediated HuR-dependent reduction in vascular cell mRNA
stability.
R.N. England, S. Kelemen, S. Ellison and M. Autieri.
Temple Univ. Sch. of Med.
A433
648.6
The effects of corn and soybean grain dusts
on the asthmatic phenotype using a murine model of fungal
allergic asthma.
A. Sharma, S.A. Hoselton, S. Ghosh and
J.M. Schuh. North Dakota State Univ.
A434
648.7
Activation of plasma kallikrein-kinin system
mediates synovial recruitment of endothelial progenitor cells
in arthritis.
J. Dai, A. Yang, R.W. Colman and Y. Wu. Soochow
Univ., China and Temple Univ.
A435
648.8
Activation of melanocortin receptor 3 as a new
strategy to control experimental and rheumatoid arthritis.
H.B.
Patel, M. Bombardieri, C. Pitzalis and M. Perretti. Barts and
The London Sch. of Med. and Dent.
SUNDAY PATHOLOGY
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A436
648.9
K/BxN-induced poly-arthritis is exacerbated
by infection with the intestinal helminth parasite Hymenolepis
diminuta: possible involvement of complement and mast cells.
R. Graepel, F.R. Jirik, K.A. Sharkey, J.J. McDougall and D.M.
McKay. Univ. of Calgary and Dalhousie Univ., Canada.
A437
648.10 Post-translational protein modification in
autoimmune epithelitis.
M. Rodriguez-Rodriguez, M.E. Pérez-
Pérez, A. Badillo-Soto, J.J. Bollain y Goytia, D. Pacheco-
Tovar, E. Avalos-Díaz and R. Herrera-Esparza. Autonomous
Univ. of Zacatecas, Mexico.
A438
648.11 Withdrawn.
A439
648.12 Disparate features of allergic airway disease
between young and old mice.
C. Brandenberger, D.N.
Jackson-Humbles, K.M. Allen, J.G. Wagner, N. Li and J.R.
Harkema. Michigan State Univ.
A440
648.13 Age changes of immunological reactivity
of an organism under the influence of low doses of gamma-
radiation.
G. Ilderbayeva, A. Abduldayeva, O. Ilderbayev and
D. Nurmukanov. Semey State Med. Univ., Kazakhstan.
649. RESOLVING THE INFLAMMATORY RESPONSE
Poster
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A441
649.1
Omega-3 derived resolvin D1 reduces the
severity of inflammatory arthritis.
L.V. Norling and M. Perretti.
Barts and The London Med. Sch., Queen Mary Univ. of London.
A442
649.2
Inhaled carbon monoxide accelerates
resolution of inflammation via novel pro-resolving mediators
and heme oxygenase-1.
M. Shinohara, N. Chiang, J. Dalli, V.
Mirakaj, A.M.K. Choi and C.N. Serhan. Brigham and Women’s
Hosp. and Harvard Med. Sch.
A443
649.3
Differential expression of pro-inflammatory and
pro-resolving lipid signaling genes in ARDS.
R-E.E. Abdulnour,
J.A. Howrylak, T. Dolinay, A. Choi and B.D. Levy. Brigham
and Women’s Hosp., Penn State Hershey Med. Ctr. and Univ.
of Tennessee Col. of Med., Chattanooga.
A444
649.4
The emerging role of the GPR109A (HCA2/
PUMA-G) receptor in regulating macrophage function.
K.
Zandi-Nejad, A. Takakura, M. Jurewicz, A. Chandraker, S.
Offermanns, D.B. Mount and R. Abdi. Beth Israel Deaconess
Med. Ctr., Brigham and Women’s Hosp. and Max Planck Inst.
for Heart and Lung Res., Bad Nauheim.
A445
649.5
Knockdown of CCR1 suppresses expression
of intercellular cell adhesion molecule-1 induced by hypoxia/
reoxygenation in endothelial cells and reduces infarct sizes
after myocardinal ischemia/reperfusion.
J. Kim, K.H. Park and
T.H. Lee. Kyung Hee Univ., South Korea.
A446
649.6
Biliverdin attenuates LPS-induced pro-
inflammatory cytokine expression in whole human blood.
K.
Bisht, B. Wegiel, J. Tampe, C.M. Shing, K.H. Wagner, L.
Otterbein and A.C. Bulmer. Griffith Univ., Australia, Beth
Israel Deaconess Med. Ctr., Harvard Med. Sch., Sch. of Human
Life Sci., Univ. of Tasmania and Univ. of Vienna.
A447
649.7
Agonist-induced conformational change of the
formyl peptide receptors.
S.N. Cooray, A. Clark, R. Flower and
M. Perretti. Barts and London Sch. of Med.
A448
649.8
Stimulating innate immunity in feedlot cattle:
strategies to induce tracheal antimicrobial peptide gene
expression.
L.M. Berghuis, J. Caswell, S. Sharif and N.
Karrow. Univ. of Guelph, Canada.
A449
649.9
Differential trafficking of the FPR2/ALX receptor
in response to endogenous or synthetic ligands.
D. Thompson
and M. Perretti. Barts and London Sch. of Med. and Dent.
A450
649.10 Macrophage dysfunction and impaired wound
healing in corneas of heme oxygenase-2 deficient mice.
L.
Bellner, G. Marrazzo, K. Castellano, M.W. Dunn and M.L.
Schwartzman. New York Med. Col.
A451
649.11 Novel design of high affinity beta-lactamase
inhibitors.
P.A. Parekh, E. Camacho Martinez, S. Zheng,
F. Bartlomiej, T.G. Palzkill and Y. Zu. The Methodist Hosp.,
Houston and Baylor Col. of Med.
A452
649.12 Modulation of the receptor ALX/FPR2 in
vascular inflammation.
M. Perretti, S. Bena, V. Brancaleone
and R.J. Flower. Barts and The London Sch. of Med. and Dent.
A453
649.13 Proteomic analysis of microparticles produced
by wound healing myofibroblast cells.
A. Langlois, S.
Larochelle, S. Siagh, H. Genest and V.J. Moulin. Laval Univ.
and Ctr. Hosp Univ. of Quebec.
650. CELL ADHESION, TISSUE INJURY AND REPAIR
Poster
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A454
650.1
Phosphoinositide-3-kinase regulation of
neutrophil mechanosensing is context dependent.
X. O’Brien,
K.E. Oakley, A.J. Loosley, J.X. Tang and J.S. Reichner.
Rhode Island Hosp., Warren Alpert Med. Sch. of Brown Univ.
and Brown Univ.
A455
650.2
Heparanase upregulation in the inflammatory
airway facilitates syndecan shedding and sustained
inflammation.
L.K.K. Wu, S.C.H. Chan, M.S.M. Ip and D.K.Y.
Shum. The Univ. of Hong Kong.
A456
650.3
Syndecan-2 regulates the invasive phenotype
of human breast carcinoma cells.
H.C. Lim, H. Multhaupt and
J. Couchman. Univ. of Copenhagen.
A457
650.4
Effect of a new compounds of substituted 5R1,
6H2-1,3,4-thiadiazine-2-amines on the histological pictures
in ligation models of experimental acute myocardial infarction
and experimental acute pancreatitis in rats.
A.P. Sarapultsev,
O.N. Chupakhin, P.A. Sarapultsev, M.A. Rantsev, S.U.
Medvedeva and I.G. Danilova. Inst. of Immunol. and Physiol.
and IJ Postovsky Inst. of Organic Synthesis, Ural Branch of
RAS , Ekaterinburg, Russian.
A458
650.5
Characterization of endometrial scarless
healing using a postpartum mouse model.
A. Yoshii, S.
Kitahara and T. Ezaki. Tokyo Womens’ Med. Univ.
A459
650.6
Cellular and molecular response of mouse
subcutaneous tissue to a triantibiotic intracanal medication.
G. Faria, M.S.S. Pereira, C.R. Cardoso, J.S. Silva, M.C.
Kuga, L.A.B. Silva and M.A. Rossi. São Paulo State Univ.,
Araraquara and Univ. of São Paulo, Ribeirão Preto.
A460
650.7
Mitochondrial reactive oxygen species
generation triggers inflammatory response and tissue injury
associated with hepatic ischemia–reperfusion: therapeutic
potential of mitochondrially targeted antioxidants.
P. Pacher, P.
Mukhopadhyay, B. Horvath, Z. Zsengeller, S. Batkai, Z. Cao,
M. Kechrid, E. Holovac, K. Erdelyi, L. Liaudet, I.E. Stillman,
J. Joseph and B. Kalyanaraman. NIAAA, NIH, Rockville, Beth
Israel Deaconess Med. Ctr., Univ. Hosp., Lausanne and Med.
Col. of Wisconsin.
PATHOLOGY SUNDAY
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A461
650.8
Characterization of the tissue response to
functional multielectrode arrays in the feline spinal nerve.
C.L. Kolarcik, C.A. Castro, X.T. Cui and D.J. Weber. Univ. of
Pittsburgh.
A462
650.9
Beneficial effects of Inchinkoto, an herbal
medicine, against the stress of major liver surgery.
Y. Yokoyama,
T. Mizutani, K. Kawai, T. Miyake, T. Kokuryo and M. Nagino.
Nagoya Univ. Grad. Sch. of Med., Japan.
A463
650.10 Concussive injury elicits human cerebrovascular
endothelial cell activation in vitro.
C. Augustine, G. Cepinskas
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