Vital Annex: International Journal of Novel Research in Advanced Sciences
(IJNRAS)
Volume: 01 Issue: 05 | 2022 ISSN: 2751-756X
http://innosci.org
396 | Page
Reasons for the Development of Morphostructural Changes in Kidney Cells in
Patients with Rheumatoid Arthritis
Mustafayeva Shargiya Akhmadovna
Assistant of the Department of Rehabilitology, Sports Medicine and Physical Education of the
Bukhara State Medical Institute named after Abu Ali ibn Sino
Annotation:
The scientific review is intended for one of the urgent problems of modern
medicine - kidney damage in rheumatoid arthritis. The issues of prevalence and risk factors of
chronic kidney disease are considered. The kidneys are affected in rheumatoid arthritis more often
than it is diagnosed.
As a result, early diagnosis of kidney damage in patients with rheumatoid
arthritis has an important clinical and prognostic value. In rheumatoid arthritis, the occurrence of
chronic kidney disease depends primarily on the duration of the disease
and the nature of the
inflammatory process. A higher incidence of RA among first-degree relatives of patients was
established than in the general population. These data are fully confirmed at the present time. The
problem of kidney damage in rheumatoid arthritis is poorly understood and requires further
research.
Keywords:
rheumatoid arthritis,
chronic kidney disease, glomerulonephritis, amyloidosis.
Rheumatic diseases are the oldest human pathology, and are considered the most common ailments
of the XXI century. In recent decades, there has been some progress in the field of theoretical and
clinical rheumatology. According to E.A. Galushko and E.L. Nasonov's rheumatic diseases include
more than 80 diseases and syndromes [31]. Rheumatoid arthritis (RA) is an autoimmune disease
characterized by the development of chronic destructive polyarthritis with frequent involvement in
tological process of other systems. Extra-articular systemic lesions in RA can have a serious impact
on the prognosis of the disease [8, 39].
Large studies conducted in recent years have demonstrated the association of RA with a high risk of
chronic kidney disease (CKD) and cardiovascular complications, which is associated with an
increase in mortality in this category of patients [9, 27,18]. The
spectrum of renal pathology
underlying CKD in RA is quite wide. Secondary amyloidosis for many years occupied the main
position among the variants of nephropathy in patients with RA [23,44]. According to some studies,
there is a tendency to change the structure of kidney damage in RA [5], given the use of highly
effective therapy regimens, including
genetically engineered drugs, which is an additional
prerequisite for studying this category of patients.
Earlier in the works of V.A. Nasonova noted that women everywhere suffer from RA more often
than men (4:1). Moreover,
in women, the incidence of RA increases with age [40].
In addition,
a higher incidence of RA was found among first-degree relatives of patients than in the general
population. These data are fully confirmed at present [3]. The formation of nephropathy in RA is
multifactorial, which is represented by the variety of their clinical and morphological variants with
minor, nonspecific changes in urine tests.
The course of rheumatoid nephropathy, as well as other chronic kidney diseases, is progressive in
nature with the development of nephrosclerosis and a decrease in
the foothold of functioning