Relevant tools and models for translation of advanced drug delivery systems sfnano Workshop 2014, 2 – 4 October 2014, Porto, Portugal



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Relevant tools and models for translation of advanced drug delivery systems

SFNano Workshop 2014, 2 – 4 October 2014, Porto, Portugal



Time

Proposed topics

Speakers

Day 1







Registration




I. Introductory presentations

9:00 – 9:45

Pharmacokinetics and pharmacodynamic concepts

Tobias Paehler, Sanofi, Germany

9:45 –10:30

Computational approaches for prediction/simulation of drug delivery

Tarek Mounir, Univ Nancy, France

10:30 – 11:00

Coffee break




11:00 – 11:45

In vitro/in vivo correlation in drug delivery

Jean-Michel Cardot, (Laboratoire Biopharmacie, Univ Clermont 1, Clermont-Ferrand)

11:45 – 12:30

Principles of Electroporation for drug delivery

Marie-Pierre Rols (Institute of pharmacology and structural biology, Toulouse, France) (A confirmer par Marie-Pierre)

12:30 – 13:15

Electroporation : characterization, tools, and constraints for in vivo delivery

Damijan Miklavcic (Univ Ljubljana, Ljubljana, Slovenia)

13:15 – 14:30

Lunch break and Networking


I. Oral route

14:30 – 15:15

Current scenario, barriers, and challenges

Clive Wilson, Univ Strathclyde, UK

15:15 – 16:00

Computational models

Michael B. Bolger, Simulations Plus, California, USA

16:00 – 16:30

Coffee break




16:30 – 17:15

In vitro models for assessment of oral drug absorption

Per Artursson

Short oral communications




17 :15 – 17 :30

PLGA particles as a vector for oral insulin delivery: in vitro and in vivo validation of biofunctionality

El Hadji Mouhamadou Bamba Diop, University of Strasbourg, France

17 :30 – 17 :45

Chitosan nanocapsules for peptide delivery

Belén L. Bouzo et al., University of Santiago de Compostela, Spain

17 :45 – 18 :00

A neurofilament-derived peptide targets neural stem cells

Joel Eyer, University of Angers, France

18 :00 – 18 :15

Improving the ability of S4(13)-PV cell-penetrating peptide to mediate siRNA delivery through peptide acylation

Catarina M. Morais et al., University of Coimbra, Portugal


Day 2

II. Parenteral route

1. Intravenous (models/tools for drug delivery to cancer and to brain)

9:00 – 9:45

Physiological barriers to drug delivery by i.v. route, clinical relevance, and challenges)

Jean Marie Devoisselle, Univ Montpellier, France

9:45 – 10:30

In vitro and in vivo models for drug delivery to cancer

Khaled Greish, Univ Otago, New Zealand

10:30 – 11:00

Coffee break




11:00 – 11:45

Electroporation in Preclinic :

Electrochemotherapy (ECT) for cutaneous cancers



Gregor Sersa ((Institute of Oncology Ljubljana, Zaloška cesta 2, SI - 1000 Ljubljana, Slovenia)

11:45 – 12:30

Targeting the Blood-brain-Barrier to improve drug delivery to the brain of low molecular drugs

Xavier Descleves, Univ Paris Descartes

12 :30 – 13:15

Targeting the Blood-brain-Barrier to improve drug delivery to the brain of macromolecules

Didier Betbeder, Lille, France

13:15 – 14:30

Lunch break and networking





2. Alternative routes: Pulmonary & Nasal, Cutaneous

14:30 – 15:15

Drug delivery through pulmonary route: Physiology, barriers, and the associated challenges

Rita Vanbever (Univ Louvain, Belgium)

15:15 – 16:00

In vitro and in vivo models for drug delivery to lung

Carsten Ehrhardt, Univ Dublin, Ireland

16:00 – 16:30

Coffee Break




Short oral communications




16:30 – 16 :45

Biodistribution, tumor targeting and melanoma anticancer properties of innovative pegylated siRNA lipid nanocapsules

Pauline Resnier et al., University of Angers, France

16:45 – 17 :00

Platform KINE C3 : relevant technological methods to assess brain bioavailability of new therapeutic compounds.

Thibaud Thiollier  et al., Cynbiose SAS, France

17:00 – 17 :15

Organized and differentiated 3D model mimicking the human pulmonary alveolar epithelium: an alternative model for drug discovery, toxicology and radiobiology

Romain Grall et al., CEA, Fontenay-aux-Roses, France

17:15 – 17 :30

Pegalation of the metal organic framework, MIL89 improves stability and

confers an inhibitory effect on iNOS activity in macrophages



Nura A Mohamed et al., Imperial college, United Kingdom

17:30 – 17 :45

Development and optimization of pegylated lipoplexes for vaginal application

Anna Lechanteur et al., University of Liege, Liege, Belgium

17:45 – 18 :00

Intrapulmonary delivery of gadolinum-based nanoparticles: a theranostic approach for lung imaging and radiosensitization

Sandrine Dufort et al. INSERM-UJF U823, Grenoble, France


Day 3

9:00 – 9:45


Drug delivery by cutaneous route: Physiology, barriers, associated challenges, and in vitro/in vivo models

B. Delgado-Charro, Bath, United Kingdom

9:45– 10:30

DNA electroporation for local delivery of therapeutic proteins and vaccines

Gaelle Vandermeulen (Louvain Drug Research Institute, Univ Catholique de Louvain, Brussels, Belgium)

10:30 – 11:00

Coffee break




11:00 – 11:45


Current clinical experience on electroporation based treatments, and future prospects


Julie Gehl (Herlev Hospital/Herlev Ringvej 75/ 2730 Herlev/Copenhagen, Denmark)

11:45 – 12:30


Nanomedicine revolution: the path through regulatory science into personalized medicine

Rogerio Gaspar, Portugal

12:30

Lunch & End of the Workshop




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