Figure 3. Photomicrograph. The strangulated ileum wall of the animals from experimental group II: Intestinal mucosa structures severely damaged by the I/R injury, (H&E stain, x200).
The histological assessment of the ileum segment from the animals of experimental group III (Prx VI) demonstrated that Prx VI administered intravenously at 15 minutes prior to I/R protected the intestine attenuating the severity of reperfusion injury after the resolution of the strangulated intestinal obstruction. The Prx VI administration posed a protective effect on the intestinal mucosa structure and the integrity of the villus-crypt architecture. However, in some parts of the strangulated ileum we observed discontinuities in the villus-crypt architecture, the leukocyte infiltration, and moderate hyperemia (Fig. 4). The ileum mucosal damage in the specimens from Group III was graded as "3 -significant epithelial lifting along the length of the villi with a few denuded villous tips " (as defined by Chiu et al.).
