Unlike Dick the Butcher

Distribution

• ↑adipose/↓lean, water

Binding/Localization

• ↓albumin

Biotransformation

• ↓Hepatic Clearance (some drugs), great variability

Elimination

• ↓GFR

Less stringent control reasonable in those with a long history of diabetes, limited life expectancy, or comorbid conditions

• Less stringent control reasonable in those with a long history of diabetes, limited life expectancy, or comorbid conditions

Hematologic

• Hematologic

• Endocrine agents

• Cardiovascular agents

• Central Nervous System Agents

• Anti-infective

Influenced by the way risk information is presented to the patient

• Influenced by the way risk information is presented to the patient

• Multimorbidity patients face more preference-based and complex decisions

• Eliciting preferences may make clinical management more time-consuming