Vital Annex: International Journal of Novel Research in Advanced Sciences (ijnras)

Vital Annex: International Journal of Novel Research in Advanced Sciences 
(IJNRAS) 
Volume: 01 Issue: 05 | 2022 ISSN: 2751-756X  
http://innosci.org 
 
398 | Page 
Currently, the leading pathogenetic mechanism for the development of glomerulo and 
tubuointerstitial changes in the kidneys is chronic inflammation. In particular, elevated levels of 
blood C-reactive protein (CRP) in patients with RA cause dysfunction of the glomerular vascular 
endothelium and trigger the synthesis of pro-inflammatory cytokines. The prognostic significance 
of an increase in the level of inflammatory markers and a decrease in glomerular filtration rate 
(GFR) in RA individuals has been noted in a few studies [20,25]. Previously published studies have 
shown that in RA patients treated with cytokine inhibitors, kidney function remained stable for a 
long time [19]. According to other data, in RA and renal amyloidosis, therapy with inhibitors of 
tumor necrosis factor alpha led to a simultaneous decrease in proteinuria [4,7]. 
The study of the pathogenesis of glomerulonephritis continues, as the existing methods of therapy 
do not have the desired effectiveness [34,]. The connection of glomerulonephritis with a change in 
the balance of cytokine synthesis associated with the mechanisms of the immune response has been 
proven [13,22]. It has been established that cytokines are involved in the regulation of proliferative 
processes, differentiation, growth, and cell activity [12,26]. 
Cytokines allow you to regulate the nature and duration of the immune response and inflammation. 
The quantitative content of cytokines and their ratio reflect the dynamics of the pathological 
process, correlate with the activity of the disease, which makes it possible to judge the effectiveness 
of the therapy and predict the outcome of the disease [42]. 
However, the degree of involvement of cytokines in the development of kidney diseases, including 
glomerulonephritis, has not been studied enough. Reports on the study of cytokine interactions in 
glomerulopathies, especially in children, are few, their results are contradictory. Based on the high 
significance of glomerulonephritis and the significant importance of the immune system in the 
pathogenesis of this disease, the study of the features of the cytokine profile in immune 
inflammation in the kidney remains a relevant and promising direction.