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Post HSCs and HPs transplantation changes of motor activity depending on the type of injury
As expected, comparison of the results, depending on type of injury, showed better progress in the cases of incomplete SCI. Sixty percent of incomplete injury cases demonstrated improved locomotion, as compared to 46.7% of complete SCI cases (Figure 5). The patterns, identified at early period of the therapy, were fully confirmed 1-3 years post therapy beginning. They are supported by the changes of clinical condition in incomplete SCI cases, manifested in the increase of motor points from baseline 142.1 ± 5.7 to 150.5 ± 5.7 after the first transplantation, and 172.6 ± 8.1 after the second transplantation (P < 0.05) (Figure 5). In complete SCI cases neurologic improvements were minimal and made only 5 points after the first HSCs and HPs transplantation (P < 0.05). The tendency to improve to 81 ± 7.9 points was observed after the second transplantation (P < 0.1), which can be explained by the insignificant number of cases (n = 11) Due to different baseline scores of incomplete SCI and complete SCI cases, the comparison between the stages of therapy was done in percent and did not demonstrated significant difference in results after the first, or after the second, and even after the twentieth HSCs and HPs transplantations.
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