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Innovations and breakthroughs
The method implies multiple long-term transplantations of the preparation of hematopoietic stem cells and hematopoietic precursors that was harvested from peripheral blood after sparing mode of administration of granulocyte colony-stimulating factor. The composition of the applied preparation is characterized. The cells are administered intrathecally in a subarachnoid space every three months and the transplantation is followed by vigorous specialized rehabilitation. The effects are evaluated by conventional indexes and tests, including somatosensory evoked potentials tests and urodynamic tests, as well as by specifically developed scales. The effects of 20 consecutive transplantations for each case are measured.
Applications
The method is safe, effective and is applicable to chronic SCI cases when no further restoration of the functions is observed. It considerably improves the life quality of the SCI patients. The method received official approval in the Russian Federation in 2005 and in 2006 and is recommended as the therapy of choice.
Terminology
Intrathecal transplantation means the infusion of the cells in the subarachnoid space in the course of lumbar puncture.
Peer-review
This is an important manuscript describing the clinical outcome of cellular therapy for spinal cord injury.
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