Extension Toxicology Network
A Pesticide Information Project of Cooperative Extension Offices of Cornell University, Michigan State University,
Oregon State University, and University of California at Davis. Major support and funding was provided by the
USDA/Extension Service/National Agricultural Pesticide Impact Assessment Program.
TRADE OR OTHER NAMES
Some trade names include Aljaden, Alloxol S, BAS 9052, Checkmate, Expand,
Fervinal, Grasidim, Nabu, NP-55, Poast, Tritex-Extra and Vantage.
Products containing sethoxydim must bear the signal word "Caution" on the label (
Sethoxydim is a selective postemergence herbicide used to control annual and
perennial grass weeds in broad-leaved vegetable, fruit, field and ornamental crops. It
also has indoor uses. It is available in emulsifiable concentrate formulations (
Sethoxydim is moderately toxic by ingestion (
), and not toxic by dermal absorption
). It causes skin and eye irritation. Inhalation of dusts or vapors can cause irritation
). Other symptoms of poisoning include incoordination,
The oral LD50 for sethoxydim in rats is 3,200 to 3,500 mg/kg. The dermal LD50 in
rats is > 5,000 mg/kg (
). The 4-hour inhalation LC50 for sethoxydim in rats is > 6.28
Long-term contact with sethoxydim can cause redness and swelling of the eyes or skin
). No adverse effects were observed in mice given 0, 2, 6, or 18 mg/kg/day for 2
). In another 2-year study with mice fed doses as high as 162 mg/kg/day, the
). The NOEL in a 1-year dog
highest dose tested was 110 mg/kg/day for males and 129 mg/kg/day for females.
Doses above the NOEL produced equivocal evidence for the occurrence of anemia
When pregnant rabbits were fed 0, 40, 160 or 480 mg/kg/day, there were decreased
litter size, low fetal weights, severe maternal weight loss, increased fetal resorptions,
spontaneous abortions, and maternal deaths at the 480 mg/kg level. The NOEL for
this study was 160 mg/kg/day (
No developmental effects were observed at any dose level when pregnant rats were
fed 0, 40, 100 or 250 mg/kg/day (
Several tests for mutagenicity of sethoxydim have produced negative results (
No carcinogenic effects were observed at any dose level when mice were fed 0, 6, 18,
54 or 162 mg/kg/day for 2 years (
No information was found.
Fate in Humans and Animals
Sethoxydim is of low toxicity to birds. The acute oral LD50 for sethoxydim in mallard
ducks is > 2,510 mg/kg. Its dietary LD50 in mallards and bobwhite quail is > 5,620
Sethoxydim is moderately toxic to trout and weakly toxic to carp (
). The LC50 for
). Its LC50
Sethoxydim has low toxicity to wildlife (
). It is non-toxic to bees (
Some degradation occurswith UV and sunlight (
Sethoxydim has a weak tendency to adsorb to soil particles (
). Laboratory soil
tests, sethoxydim did not leach below the top 4 inches of soil and it did not persist (
). The product
life on a loamy sand at pH 6.8 was 4 to 5 days, and on a loam soil at pH 7.4 was 11
In water, photodegradation of sethoxydim takes less than 1 hour (
Breakdown of Chemical in Vegetation
Sethoxydim is absorbed rapidly by foliage and moves both upward and downward in
plants from the point of absorption. Sethoxydim was rapidly metabolized in soybeans
). The product Poast does accumulate in the tissues of crops planted in fields after
Sethoxydim is an yellowish-brown, oily liquid (
). Formulated products containing
sethoxydim decomposes at room temperature (
). Thermal decomposition of
Workers handling sethoxydim should avoid contact of this material with eyes, skin or
No occupational exposure limits have been established for sethoxydim by OSHA,
NIOSH or ACGIH (
safety margin (
1.043 at 25 degrees C (technical) (
readily soluble in most organic solvents; freely soluble in methanol,
hexane and xylene (
> 194 degrees F (> 90 degrees C) (
unstable at room temperature if not formulated (
Agricultural Products Group
2505 Meridian Pkwy.
Research Triangle Park, NC 27709-3528
Review by Basic Manufacturer:
Comments solicited: April, 1993
Company, Willoughby, OH.
Occupational Health Services, Inc. 1992 (Nov. 17). MSDS for Sethoxydim.
SCS/ARS/CES Pesticide Properties Database: Version 2.0 (Summary). USDA -
Soil Conservation Service, Syracuse, NY.
Weed Science Society of America, 6th Ed. WSSA, Champaign, IL.
British Crop Protection Council. 1983. The Pesticide Manual: A World
for 2[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-hydroxy- 2-cyclohexen-
1-one. Federal Register 56 (54): 11677-8.
Fate One Line Summary: Sethoxydim. Environmental Fate and Effects
Division, US EPA, Washington, DC.
Sethoxydim. US EPA, Washington, DC.