Santos, V.U. Melo, F. Macedo, J.L.B. Alves, M.R.V. Santos,
L.R. Oliveira, M.N.S. Santana, M. Matiotti, L.C. Brito, E.
Nascimento, J.H.C. Silva and V.J. Santana-Filho. Fed. Univ.
of Sergipe and Fed. Univ. of Pernambuco, Brazil.
W220
1187.7 IGF-1 induces proliferation and T
3
causes
maturation of cultured embryonic chicken cardiomyocytes.
A-C.B. Svensson-Holm, I. Lindgren, H. Österman and J.
Altimiras. Linköpings Univ., Sweden.
W221
1187.8 Study of zebrafish cardiac morphogenesis
using computational fluid dynamics.
J. Lee, H. Cao and T.K.
Hsiai. Univ. of Southern California.
W222
1187.9 Effect of chronic stress on cardiovascular
function in adolescent and adult.
J.O. Duarte. São Paulo State
Univ.
W223
1187.10 Long-term hypoxia impairs ryanodine receptor
function and regulation by cyclic nucleotides in immature and
mature pulmonary arterial myocytes.
S. Hough, M. Rubalcava,
C. Manjunath, Q. Blood, L.D. Longo and S.M. Wilson. Loma
Linda Univ.
W224
1187.11 Constraining effects the CFTR-
D
F508 mutation
on myocyte calcium release, aortic tone and arterial blood
pressure.
V. Peotta, K.A. Volk, J. Guo and R.D. Roghair. Univ.
of Iowa Carver Col. of Med.
W225
1187.12 Balancing complexity and simplicity in
mathematical models of Fontan circulations.
M.W. Mohiuddin,
S.F. Knezek and C.M. Quick. Michael E. DeBakey Inst. and
Texas A&M Univ.
W226
1187.13 Source identification of QT interval changes
in diabetic patients.
S. Wang, J.M. Evans, C.F. Knapp, T.T.
Schlegel, S.C. Elayi and A.R. Patwardhan. Univ. of Kentucky
and NASA Johnson Space Ctr.
W227
1187.14 Improving the redox potential of gestational
diabetic endothelial cells: protective actions of sulforaphane.
B.
Patel, R.C.M. Siow and G.E. Mann. King’s Col. London.
W228
1187.15 Expression of (pro)renin receptor and
angiotensin II type 1 receptor on bone marrow-related neurons
in the central nervous system.
C.D. Kimball, W. Li, A. Zsombok,
A. Derbenev, J. Francis, M.K. Raizada and Y. Feng. Tulane
Univ. Sch. of Med., LSU Sch. of Vet. Med. and Univ. of Florida
Col. of Med.
W229
1187.16 Enhanced apoptosis may lead to fewer
nephrons in Japanese quail subjected to reduced nutrition
during development.
H. Nishimura, Y. Nishi, M. Nameta,
K. Kidokoro, M. Satoh, K. Yamaguchi, T. Shimada and N.
Kashihara. Niigata Univ. of Hlth. and Welfare, Kawasaki Med.
Sch. and Sch. of Med. and Dent. Sci., Niigata Univ., Japan.
PHYSIOLOGY WEDNESDAY
421
W
E
D
1188. EXTRACELLULAR MATRIX AND CARDIAC
REMODELING
Poster
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. 7:30
am
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7:30 AMW230
1188.1 Lithium promotion of connexin43
protein in infarcted rats by Wnt- and PI3K/Akt-dependent GSK-
3
b phosphorylation signaling. T-M. Lee and Y-J. Hsu. China
Med. Univ., An-Nan Hosp., Tainan.
7:31 AMW231
1188.2 Dipeptidyl peptidase IV inhibition
attenuates ventricular vulnerability via cAMP/PKA/CREB
pathway.
T-M. Lee and Y. Hsu. China Med. Univ., An-Nan
Hosp., Tainan.
7:32 AMW232
1188.3 Adenosine A2A and A2B receptors
differentially modulate signal transduction and collagen
production in murine cardiac firboblasts.
E. Zhan, V. McIntosh,
F. Wang, R. Maruthi, B. Kadi, M. DeMerle and R. Lasley.
Wayne State Univ.
7:33 AMW233
1188.4 Rap1a mediates extracellular matrix
remodeling through AGE/RAGE signaling in diabetes mellitus.
R. Randive, S.C. Jeyaraj, M.A. Chotani and J.A. Stewart, Jr.
Mississippi State Univ., Nationwide Children’s Hosp. and The
Ohio State Univ.
7:34 AMW234
1188.5 AGE/RAGE and PKC-zeta interplay
in 3D matrix mediated fibroblast differentiation.
C.M. Cerovsky,
Z.N. Syed and J.A. Stewart, Jr. Mississippi State Univ.
7:35 AMW235
1188.6 Functional characterization of
KLK 8 in cardiomyocytes: cardioprotection and induction of
hypertrophy.
X. Ni, B. Cao, X. Zhu, W. Zhao and Z. Tang.
Second Military Med. Univ. and Shanghai Univ. of Sport, China.
7:36 AMW236
1188.7 Salt-induced cardiac hypertrophy
is blood pressure independent and prevented by losartan
and N-acetylcysteine.
I.A. Katayama, R.C. Pereira, M.H.M.
Shimizu and J.C. Heimann. Univ. of São Paulo.
7:37 AMW237
1188.8 Use of non-cardiac fibroblasts to
create three-dimensional and functionally active cardiac fibers.
Z. Karabekian, A. Jamshidi, H. Ding, N.G. Posnack and N.
Sarvazyan. George Washington Univ.
7:38 AMW238
1188.9 Aldosterone activates autophagy to
increase fibroblast collagen synthesis and vascular stiffness.
S. Torquato, B.A. Maron, R. Aghamehammadzadeh, J.
Loscalzo and J.A. Leopold. Brigham and Women’s Hosp. and
Univ. of Manchester.
7:39 AMW239
1188.10 Ski inhibits Scleraxis function: effect
on collagen expression in cardiac myofibroblasts.
M. Zeglinski,
R. Cunnington, J. Davies, M. Kavosh, S. Gupta, K. Bathe, S.
Rattan, M. Czubryt and I. Dixon. Univ. of Manitoba.
1189. GENE EXPRESSION AND CARDIOVASCULAR
FUNCTION
Poster
W
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W240
1189.1 Role of estrogen receptor
a in estradiol-
induced cardiac growth.
G. Kararigas, B.T. Nguyen and H.
Jarry. Charité Univ. Hosp., Berlin, Goettingen Univ. Hosp. and
Hanoi Univ. of Agr.
W241
1189.2 Platelets activated during myocardial infarction
release functional miRNA which can be taken up by endothelial
cells and regulate ICAM1 expression.
O. Gidlof, M. van der
Brug, J. Ohman, P. Gilje, B. Olde, C. Wahlestedt and D.
Erlinge. Lund Univ., Sweden, Genentech and Miami Univ.
Miller Sch. of Med.
W242
1189.3 Identification of altered plasma proteins by
proteomic study in valvular heart diseases and the potential
clinical significance.
G-W. He, G. Gao, C. Xuan, X-Y. Bai, X-C.
Liu, W-B. Jing and Q. Yang. TEDA Intl. Cardiovasc. Hosp.,
Med. Col., Nankai Univ., China, Oregon Hlth. & Sci. Univ. and
The Chinese Univ. of Hong Kong.
W243
1189.4 Over-expression of FXRG and miR-1 increases
formation of RISC complexes in H9C2 cell line.
L. Walker, K.
Dockstader, D. Slavov and C. Sucharov. Amherst Col. and
Univ. of Colorado Denver, Aurora.
W244
1189.5 Retinoic acid-induced regulation of guanylyl
cyclase/natriuretic peptide receptor-A gene expression in
gene-targeted mice via histone H3 modifications.
P. Kumar, R.
Periyasamy, S. Das and K.N. Pandey. Tulane Univ. Hlth. Sci.
Ctr.
W245
1189.6 Structural remodeling in the left ventricle of
streptozotocin-induced type 1 diabetic rat.
J. Singh, K. Bidasee,
C. Moore, T. Iqbal and A. D’Souza. Univ. of Nebraska Med.
Ctr. and Univ. of Central Lancanshire, U.K.
W246
1189.7 Myocardial gene expression of the tinamou
reflects the physiological challenges of having a small heart.
H.
Österman, A. Ekström, Á. Garitano-Zavala and J. Altimiras.
Linköpings Univ., Sweden and Univ. Mayor de San Andrés,
Bolivia.
W247
1189.8 Potential proarrhythmic alterations in
ventricular cardiomyocytes expressing CREM-Ib
DC-X, a
repressory human cardiac isoform of cAMP response element
modulator.
J.S. Schulte, E. Fehrmann, M. Tekook, A. Heinick,
M.D. Seidl, W. Schmitz and F.U. Müller. Univ. of Muenster.
W248
1189.9 No cardiac hypertrophy induced by T3 in a
mouse model of the syndrome of resistance to thyroid hormones.
G.E. Império, G.F. Pereira, I.P.R. Freitas, L.A. Santiago, N.A.
Almeida, C.S. Fuziwara, E.T. Kimura, E.L. Olivares and T.M.
Ortiga-Carvalho. Fed. Univ. of Rio de Janeiro, Fed. Rural Univ.
of Rio de Janeiro and Univ. of São Paulo.
W249
1189.10 Allelic variability in the AGT M235T and AT1
A1166C single nucleotide polymorphisms from a cohort of
east Africans.
N.A. Rice, J.C. Freeman and B.M. Lengube.
Western Kentucky Univ.
W250
1189.11 A role for Nrf2 in the prevention of salt-induced
vascular dysfunction.
J.R.C. Priestley, A.F. Dahlgren, B.D.
Weinberg, J.M. McCord and J.H. Lombard. Med. Col. of
Wisconsin and Univ. of Colorado Denver, Aurora.
W251
1189.12 High altitude long-term hypoxia: gene
expression in adult ovine carotid arteries.
R. Goyal, N. Matei
and L.D. Longo. Loma Linda Univ.
WEDNESDAY PHYSIOLOGY
422
1190. GENETIC MODELS OF CARDIOVASCULAR
FUNCTION
Poster
W
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7:30 AMW252
1190.1 Relationship between dyslipidemia
and hypertension in male ZDSD, a new rat model of metabolic
syndrome.
D.M. Eaton, A.N. Rogers, A.E. Rice, K. Coy, R.G.
Peterson and C.S. Packer. Purdue Univ., Indiana Univ. Sch. of
Med. and PreClinOmics, Indianapolis.
7:31 AMW253
1190.2 Female murine Egr-1 homozygous
negative estrus cycle characterization.
A.K. Baldwin, R.P.
Gersch, T.K. Rosengart and M.D. Frame. Stony Brook Univ.
1191. MYOCARDIAL ISCHEMIA/MYOCARDIAL
METABOLISM II
Poster
W
eD
. 7:30
am
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C
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W254
1191.1 Apocynin exerts dose-dependent
cardioprotective effects by attenuating reactive oxygen species
in ischemia/reperfusion.
L. Young, C. Parker, R. Barsotti, K.
Bartol, T. Habtamu, J. Tolson, D. Koko, B. Diaz, B. Casey, R.
Ondrasik and Q. Chen. Philadelphia Col. of Osteo. Med.
W255
1191.2 Sympathetic and metabolic changes induced
by hyperglycemia in myocardial infarction.
C. Malfitano, M.
Carbonaro, A.L. de Souza, Jr., A.B. Lopes, D.E. Casarini, R.
Curi, K. De Angelis and M.C. Irigoyen. Univ. Nove de Julho,
Brazil, Univ. of São Paulo and Fed. Univ. of São Paulo.
W256
1191.3 Decreased fatty acid oxidation impairs
contractile recovery of the insulin-resistant heart post-
ischemia.
R. Harmancey, H.G. Vasquez, P.H. Guthrie and H.
Taegtmeyer. Univ. of Texas Med. Sch. at Houston.
W257
1191.4 The mitochondria-targeting peptide Bendavia
protects the heart against ischemia-reperfusion injury without
abolishing ischemic preconditioning.
L.M. Stewart, J.Q. Lloyd,
H.D. Patel, F. Moukdar and D.A. Brown. East Carolina Univ.
W258
1191.5 Endothelial nitric oxide synthase
S-glutathionylation and Ser1177 phosphorylation modulate
myocardial protection.
M.A.H. Talukder, C. Yang, S. Varadharaj,
C-A. Chen and J.L. Zweier. The Ohio State Univ.
W259
1191.6 BKCa
2+
channel inhibition improves myocardial
stunning following hyperkalemic cardioplegic arrest but not
reversible ischemia: potential role of ROS and GSK3B.
B.
Cordeiro and R.T. Clements. Rhode Island Hosp. and Alpert
Med. Sch. of Brown Univ.
W260
1191.7 Role of caveolin-3 in adenosine-induced
increase in mitochondrial PKC
ε
.
C. Kang and K. Hu. The Ohio
State Univ.
1192. NUTRIENTS AND CARDIOVASCULAR HEALTH
AND DISEASE: GLUCOSE, FATTY ACIDS AND
BEYOND (POSTERS)
Poster
W
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W261
1192.1 Fish oil and neurovascular reactivity to mental
stress in humans.
J.R. Carter, C.E. Schwartz, H. Yang and
M.J. Joyner. Michigan Technol. Univ., New York Med. Col. and
Mayo Clin.
W262
1192.2 Postprandial blood glucose response to meals
of varying composition: influence of BMI and physical fitness.
M.K. Hopper, C.E. Koch and J.L. Koch. Univ. of Southern
Indiana.
W263
1192.3 Decreased mitochondrial respiratory capacity
does not correlate with worsened LV function in heart failure.
K.A. O’Connell, J. Cox, W. Xu, K.C. Shekar, D. Gamble, B.
Woodman and W.C. Stanley. Univ. of Maryland Baltimore.
W264
1192.4 C9,t11-conjugated linoleic acid alters hdl
functionality.
N. Nicod, P.S. Parker, E. Giordano, A. Dávalos
and F. Visioli. IMDEA Food, Spain and Cornell Univ.
W265
1192.5 Garlic ( Allium sativum) attenuates glomerular
glycation in streptozotocin-induced diabetic rats.
K.K. Al-
Qattan, M. Thomson, M. Ali and M.H. Mansour. Kuwait Univ.
W266
1192.6 The effects of palmitic acid and oleic acid on
macrophage gene expression.
A. Delos Reyes, C. Camell,
C.W. Smith and R.E. Rumbaut. Baylor Col. of Med. and
Michael E. DeBakey VA Med. Ctr.
W267
1192.7 Leptin induces adiponectin expression:
implications in obesity.
P. Singh, K.R. Sahakyan, F.H. Sert-
Kuniyoshi, A. Romero-Corral, S. Delacroix, D.E. Davison,
M.D. Jensen and V.K. Somers. Mayo Clin.
W268
1192.8 Exploring mechanisms that attenuate
myocardial glucose uptake in response to acute hyperglycemia:
identification of a vicious metabolic cycle.
D. Joseph, C.P.
Kimar and M.F. Essop. Stellenbosch Univ., South Africa.
W269
1192.9 Acute effects of a mixed meal on arterial
stiffness and central hemodynamics in healthy adults.
J.L.
Taylor, T.B. Curry, L.J. Matzek, M.J. Joyner and D.P. Casey.
Mayo Clin.
W270
1192.10 Nf-
kB dependent mechanisms of high fat
mediated cardioprotection.
L. Haar, X. Ren, N. Bertaux-
Skeirik, T. Tee, M. Tranter and W.K. Jones. Univ. of Cincinnati.
W271
1192.11 Effect of oligomerized polyphenol
supplementation on lipid metabolism during exercise in
healthy men.
T. Miyake, K. Sato, K. Matsutani, M. Iemitsu, M.
Nishizawa, T. Miura, T. Isaka and S. Fujita. Ritsumeikan Univ.,
Japan and Amino Up Chem. Co., Ltd., Sapporo.
W272
1192.12 Canonical correlation analysis identifies key
diet macronutrients related with metabolic and cardiovascular
disorders in rodents submitted to hypercaloric diet.
S.A.
Oliveira, Jr., C.R. Padovani, N.R. Silva, P.F. Martinez, D.H.S.
Campos, M.P. Okoshi, K. Okoshi and A.C. Cicogna. Fed.
Univ. of Mato Grosso do Sul and UNESP, Botucatu, Brazil.
W273
1192.13 Effects of chronic green tea or green tea extract
treatment in cardiovascular function in hypertensive rats.
M.L.
Garcia, E.E. Nishi, G.S. Lincevicius, G.R.L. Veiga, R.B.
Pontes, R.R. Campos, L. Oyama and C.T. Bergamaschi.
Fed. Univ. of São Paulo.
PHYSIOLOGY WEDNESDAY
423
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W274
1192.14 Chronic interval exercise modifies the
myocardial lipid profile in a miniature swine model of heart
failure with preserved ejection fraction.
C.A. Emter, R.S.
Rector, C.P. Baines, K.D. Ford and D.A. Ford. Truman VA and
Univ. of Missouri-Columbia and Saint Louis Univ.
W275
1192.15 Glyoxal and methylglyoxal but not
4-hydroxynonenal and malondialdehyde form adducts on
cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic
reticulum Ca
2+
ATPase in diabetes.
K. Bidasee, F. Alomar, J.
Singh and C. Moore. Univ. of Nebraska Med. Ctr. and Univ. of
Central Lancanshire, U.K.
W276
1192.16 Differences in the biosynthesis of long chain
omega-3 and omega-6 polyunsaturated fatty acids between
African and European American patients with coronary artery
disease.
B.A. Wilson, P. Ivester, S. Sergeant, K. Murphy, W.G.
Hundley and F.H. Chilton. Wake Forest Univ. Sch. of Med.
W277
1192.17 Specialized role of Ca
2+
-activated K
+
channels
in signaling responses of different brain cell types.
D.
Gebremedhin. Med. Col. of Wisconsin.
W278
1192.18 Circulating microRNA profiling and their
association with hypoadiponectinemia.
F. Hassan, S.A.
Sammy, A. Trecartin, J.B. Alley, F. Bovenzi, D. Bohman,
L. Fitzgerald, J-M. Prot, M.L. Schuler and M. Ariza-Nieto.
Cornell Univ. and Guthrie Fndn. for Educ. and Res., Sayre, PA.
W279
1192.19 Heterogeneity of cardiac myocyte contractile
properties during long-term stimulation: substrate effects.
G.
Barton and G. Diffee. Univ. of Wisconsin-Madison.
W280
1192.20 Short- and long-term fructose feeding alters
exercise capacity of rats.
A. Sun, E. Kertowidjojo, S. Song
and T.H. Hintze. New York Med. Col.
W281
1192.21 Nox2 deficiency limits the development of
insulin resistance produced by a high-fat diet.
S.P. Didion.
Univ. of Mississippi Med. Ctr.
W282
1192.22 High fat intake with monounsaturated fatty
acids, but not n6 polyunsaturated fatty acid, increases activity
of key mitochondrial oxidative enzymes in the heart.
J.W. Cox,
K. O’Connell, W. Xu and W.C. Stanley. Univ. of Maryland Sch.
of Med.
W283
1192.23 Glutathione peroxidase-4 plays a critical role in
protection from metabolic syndrome and cardiac remodeling
caused by diet-induced obesity.
L.A. Katunga, T.A. Mattox,
S.M. Abernathy, T.M. Darden, J. Virag and E.J. Anderson.
East Carolina Univ.
W284
1192.24 Adaptation of the heart to high dietary fat:
rapid inhibition of pyruvate dehydrogenase.
C.L. Crewe, M.
Kinter and L. Szweda. Univ. of Oklahoma Hlth. Sci. Ctr. and
Oklahoma Med. Res. Fndn.
W285
1192.25 Acute oral amino acid intake increases both
secretion and breakdown of very low density lipoprotein-
triacylglycerol.
N.M. Hurren, C. Porter, M. Chondronikola, C.
Yfanti, E. Volpi, L.M. Belalcazar, M. Kinsky, L. Sidossis and
E. Børsheim. Univ. of Texas Med. Branch and Shriners Hosps.
for Children.
1193. SHOCK
Poster
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W286
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