1209.18 Lifestyle intervention reduces skeletal muscle
dynamin-related protein-1 activation in obese insulin-resistant
humans.
C.E. Fealy, A. Mulya and J.P. Kirwan. Cleveland Clin.
W484
1209.19 Effect of chronic heart failure on mitochondrial
function and apoptotic susceptibility in rat skeletal muscle.
L.M-D. Nguyen, S.D. Carey-Love, B. Ahn, L.F. Ferreira and
P.J. Adhihetty. Univ. of Florida.
W485
1209.20 Characterization of different modes of Ca
2+
uptake under physiological conditions in heart mitochondria.
S.
Tewari, R.K. Pradhan, J.N. Bazil, A.K.S. Camara, D.F. Stowe,
D.A. Beard and R.K. Dash. Med. Col. of Wisconsin.
W486
1209.21 Impact of dietary induced fatty liver on
mitochondrial oxidative phosphorylation.
C. Newell, C. Hughey,
V. Nyamandi, V. Johnsen and J. Shearer. Univ. of Calgary,
Canada.
W487
1209.22 Dynamic expression and localization of protein
kinase A regulatory subunit RI
a in cardiac mitochondria
controls response to oxidative stress.
K. Haushalter, H.H.
Patel and S. Taylor. UCSD and VA San Diego Healthcare Syst.
W488
1209.23 Characterizing the co-occurrence between
mitochondrial KATP channel and uncoupling proteins in type 2
diabetes.
A. Brito, L. Peltekian, S. Mandala, N. Gonzalez, V.
Lopez and K. Yamazaki. California State Univ., Los Angeles.
W489
1209.24 Mouse embryonic fibroblasts devoid of both
mitofusin1 and mitofusin2 can acutely shift from glycolytic
to oxidative metabolism.
E. Seifert, C. Moffat and E. Strus.
Thomas Jefferson Univ.
W490
1209.25 Severe thermal trauma alters adipose tissue
mitochondrial function in children.
C. Porter, M. Chondronikola,
D.N. Herndon, E. Børsheim and L.S. Sidossis. Shriners
Hosps. for Children and Univ. of Texas Med. Branch.
1210. REGULATION OF EPITHELIAL TRANSPORTERS
AND PUMPS
Poster
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W491
1210.1 Cytoplasmic Hsp70 and Hsp90 regulate
functionally distinct ER quality control checkpoints during
thiazide-sensitive NaCl cotransporter biogenesis.
B.F.
Donnelly, P.G. Needham, A.C. Snyder, A. Roy, S. Khadem,
J.L. Brodsky and A.R. Subramanya. Univ. of Pittsburgh Sch.
of Med., Univ. of Pittsburgh and VA Pittsburgh Healthcare Syst.
W492
1210.2 SPAK’s kinase activity and WNK4 expression
are not essential for NCC activation under low K
+
diet.
M.
Castaneda-Bueno, L.G. Cervantes-Perez and G. Gamba.
UNAM and INNSZ, Mexico City.
W493
1210.3 Sexual dimorphic regulation of NCC involves
higher SPAK and NCC phosphorylation in female rodents.
L.
Rojas-Vega, M. Castañeda-Bueno, L.G. Cervantes-Perez,
L. Reyes-Castro, H.D. Hernandez, E. Zambrano and G.
Gamba. UFM-IIB-UNAM and INNSZ, Mexico City.
W494
1210.4 VAMP3 mediates NKCC2 trafficking in thick
ascending limbs and is required for normal renal function and
blood pressure.
P.S. Caceres, M.Z. Haque and P.A. Ortiz.
Henry Ford Hosp. and Wayne State Univ.
W495
1210.5 Calcium regulates Na
+
:K
+
:2Cl
-
cotransporter
function in Malpighian tubules of Rhodnius prolixus.
P. Gioino
and J.P. Ianowski. Univ. of Saskatchewan.
W496
1210.6 Role of the renal mineralocorticoid receptor
for potassium homeostasis.
M. Roesinger, D. Loffing-Cueni,
C. Ronzaud, J. Canonica, A. Debonneville, E. Hummler, O.
Staub and J. Loffing. Univ. of Zurich and Univ. of Lausanne.
W497
1210.7 Rapid homeostatic effects of oral potassium
loading on the kidney.
S. Grossmann, M.V. Sorensen, M.A.
Roesinger, D. Loffing-Cueni, G. Barmettler, U. Ziegler, A.
Odermatt and J. Loffing. Univ. of Zurich and Univ. of Basel.
W498
1210.8 Renal mechanisms driving K excretion after a
K containing meal.
S. Rengarajan, J.H. Youn, D.H. Lee and
A.A. McDonough. Univ. of Southern California.
W499
1210.9 Hyperglycemia, low salt diet, and metabolic
acidosis increase the expression of KCcl cotransporters in the
kidney.
Z. Melo, R. Bautista, S. Cruz-Rangel, N. Bobadilla,
G. Gamba and A. Mercado. UFM-IIB-UNAM, INNSZ, INCICH
and IFC-UNAM, Mexico City.
W500
1210.10 NO regulation of Na,K-ATPase in ocular ciliary
epithelium involves Src family kinase.
M. Shahidullah, A.
Mandal, G. Wei and N.A. Delamere. Univ. of Arizona.
W501
1210.11 Activation of intestinal NHE3 by insulin
depends on the coordination of IRBIT, NHERF1, and Ezrin.
P.
He, S. Srinivasan and C. Yun. Emory Univ.
W502
1210.12 Lactoferrin ameliorates prostaglandin E2-
mediated inhibition of Na-glucose cotransport in enterocytes.
J. Talukder, N. Muhammad, R. Williams, L. Johnson and J.
Wright. LeMoyne-Owen Col., TN.
W503
1210.13 Leptin but not its long form receptor
regulates intestinal membrane expression of sodium/glucose
transporter-1 and intestinal hyperplasia.
J.A. Dominguez
Rieg, M. Gerasimova, H. Koepsell and T. Rieg. Bastyr Univ.
California, VA San Diego Healthcare Syst., Univ. of Wuerzburg
and UCSD.
W504
1210.14 PTH-stimulated urinary phosphate and cAMP
excretion are absent in mice lacking adenylyl cyclase 6.
T. Rieg,
M. Sharik, T. Tang, N. Aroonsakool and F. Murray. UCSD and
VA San Diego Healthcare Syst.
W505
1210.15 Parathyroid hormone decreases mRNA
stability of the type IIa sodium-phosphate cotransporter
(NpT2a).
R. Murray, N. Lesousky, S.J. Khundmiri, B. Clark
and E. Lederer. Univ. of Louisville and Robley Rex VA Med. Ctr.
W506
1210.16 Aurora kinase A regulates the vacuolar H
+
-
ATPase in kidney carcinoma cells.
M.M. Al-bataineh, R.
Alzamora, F. Gong, A.L. Marciszyn, K.R. Hallows and N.M.
Pastor-Soler. Univ. of Pittsburgh.
W507
1210.17 PSD-95 interacts with NBCn1 and enhances
channel-like activity without affecting cotransport function.
S.
Lee and I. Choi. Emory Univ.
W508
1210.18 Liver X receptor activation inhibits intestinal
phosphate transport.
S. Jelen, H. Giral, Y. Caldas, E.
Sutherland and M. Levi. Univ. of Colorado, Aurora.
W509
1210.19 Urea channel Slc14a2 interactome in rat inner
medullary collecting duct.
C.L. Chou, L. Han, T. Pisitkun and
M.A. Knepper. NHLBI, NIH.
W510
1210.20 Glycan binding protein galectin-3 negatively
regulates UT-A1 urea transport activity by impairing protein
membrane expression.
X. Li, B. Yang, O. Fröhlich, R.P.
Hughey and G. Chen. Emory Univ., Peking Univ., Beijing and
Univ. of Pittsburgh.
PHYSIOLOGY WEDNESDAY
433
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W511
1210.21 Basolateral amino acid transport investigated
using MDCK epithelia and mouse models.
A. Guetg, M.
Torrente, L. Mariotta, S.M.R. Camargo and F. Verrey. Inst. of
Physiol. and Ctr. for Integrat. Human Physiol., Zurich.
1211. PHYSIOLOGICAL GENOMICS OF EXERCISE
AND BODY MASS, EXPERIMENTAL MODELS
Poster
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Presentation time: 12:30
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W512
1211.1 Molecular insights into mild exercise-induced
enhancement of spatial memory and neurogenesis: a DNA
microarray approach.
K. Inoue, M. Okamoto, M.C. Lee, T.
Matsui, R. Rakwal and H. Soya. Univ. of Tsukuba, Japan.
W513
1211.2 Bioinformatic analysis of specificity in signaling
that controls smooth muscle tone.
R.P. Dippold and S. Fisher.
Univ. of Maryland Baltimore.
W514
1211.3 Novel role for perinatal myosin in skeletal
muscle development.
D.C. Wilkes, K. Charitakis, J.S. Lee and
C.J. Hatcher. Weill Cornell Med. Col.
W515
1211.4 Generation of caveolin-2 overexpressing C.
elegans and their response to stress.
E. Shi, H.N. Fridolfsson,
E. Kwan, J.M. Schilling and H.H. Patel. UCSD and VA San
Diego Healthcare Syst.
1212. POPULATION GENETICS, MODEL ORGANISM
TRANSCRIPTOMICS, GENE EXPRESSION
Poster
W
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Presentation time: 12:30
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-2:15
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W516
1212.1 Prevalence of Gly482Ser polymorphism of
PPARGC1A in Cuban Americans.
A.K. Cheema, G.G. Zarini,
J.A. Vaccaro, L. Shaban, M.T. Dorak and F.G. Huffman.
Florida Intl. Univ. and Col. for Women, Kuwait Univ.
W517
1212.2 Mechanisms of population level variation in
fatness and leanness.
A. Wells, S. Das, B. Ji and B. Voy. Univ.
of Tennessee, Knoxville.
W518
1212.3 Genetics of physical performance in U.S.
Marines.
A. Jensen, R. Congalton, B. Niederberger, R.
Jaworski and K. Kelly. Naval Hlth. Res. Ctr., San Diego and
Marine Corps Systs. Command, Quantico, VA.
W519
1212.4 Identification of candidate susceptibility genes
in a murine model of respiratory syncytial virus-induced
bronchiolitis.
K.C. Verhein, M. High, J. Marzec, Z. McCaw, T.
Wiltshire, Y. Chen, A. Burkholder, L. Klimczak, D. Fargo and
S.R. Kleeberger. NIEHS, NIH, Research Triangle Park and
Univ. of North Carolina at Chapel Hill.
W520
1212.5 Regulation of adipogenesis and key
adipogenic gene expression by nutritional molecules in 3T3L1
preadipocytes.
S. Ji, P. Cheguru, S. Acharya and R.A. Hill.
Univ. of Idaho and the Univ. of Iowa Col. of Med.
W521
1212.6 Cardiac CARD9 mRNA expression in inbred
rat strains divergent in survival time after severe hemorrhage.
T. Oh and H.G. Klemcke. U.S. Army Inst. of Surg. Res., Fort
Sam Houston.
W522
1212.7 Cardiorespiratory fitness affects polymorphism
in ADRB3 Trp64Arg-caused increase in common carotid
intima-media thickness.
S. Fujie, M. Iemitsu, H. Murakami,
K. Sanada, H. Kawano, Y. Gando, R. Kawakami and M.
Miyachi. Ritsumeikan Univ., Natl. Inst. of Hlth. and Nutr., Tokyo
and Waseda Univ., Japan.
W523
1212.8 Carbon nanotube, nanosilver and nanoclay
protein corona composition in cell culture media.
X. Lai, J.H.
Shannahan, R. Chen, P-C. Ke, S. Mitra, J.M. Brown and F.A.
Witzmann. Indiana Univ. Sch. of Med., East Carolina Univ.,
Clemson Univ. and New Jersey Inst. of Technol.
W524
1212.9 Age-dependent differential gene expression
in exposure-response of contraction-induced muscle injury.
J.
Ensey, S. Li, M.L. Kashon, M.S. Hollander, R.G. Cutlip and
B.A. Baker. NIOSH and West Virginia Univ. Sch. of Med.
W525
1212.10 Comparative genomics identifies the mouse
Bmp3 promoter and an upstream evolutionary conserved
region in mammals.
J.W. Lowery, A.W. LaVigne, S. Kokabu
and V. Rosen. Harvard Sch. of Dent. Med.
W526
1212.11 The genetic association of polymorphism
rs2383207 in chromosomal locus 9p21, with coronary artery
disease.
N. Rizk, F. Dadbakhsh Arzemohmmed, S.E. Ebrahim
and A. Ahmed El-Menyar. Qatar Univ.-CAS, Hammed Med.
Corp., Doha and Weill Cornell Med. Sch., Qatar.
W527
1212.12 Hyperoxia enhances response to respiratory
syncytial virus infection.
W. Gladwell II, L. Middleton, D. Cook,
S.R. Kleeberger and J. Ciencewicki. NIEHS, NIH, Research
Triangle Park and Stanford Univ. Sch. of Med.
W528
1212.13 Genome-wide association mapping of
vasoreactivity in thoracic aorta from inbred mice.
S.K. Kim, J.J.
Avila and M.P. Massett. Texas A&M Univ.
W529
1212.14 A systems biology analysis of the genomics of
probenecid action in the late gestation ovine fetal pituitary.
C.
Wood, M.B. Rabaglino, E. Chang and E. Richards. Univ. of
Florida.
W530
1212.15 Identifying metabolic pathways associated
with leanness using domestic chickens as a model.
B. Ji, S.
Lamont, J. Middleton, A. May, S. Campagna and B. Voy.
Univ. of Tennessee, Knoxville and Iowa State Univ.
1213. SYSTEMS BIOLOGY, COMPUTATIONAL
MODELING AND BIOINFORMATICS
Poster
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W531
1213.1 A dual role for nucleolin identified by systems
analysis of cardiac chromatin remodelers.
E. Monte, K.
Mouillesseaux, H. Chen, S. Ren, Y. Wang, J-N. Chen, T.M.
Vondriska and S. Franklin. UCLA and Univ. of Utah.
W532
1213.2 An interactive quantitative temporal
physiological model of glucose passage and absorption
through the gastrointestinal tract and subsequent modulation of
insulin and glucagon secretion in humans.
S.A. Garan, S. Sun,
H.K. Gurm, A. Chen, A. Govinthasamy, G. Efe, T.H. Chen, S.
Sachaphimukh, S. Plamthottam, B. Goitom, N. Banerjee, R.
White, B. Ahmed, A. Sarcon, W. Freitag, L.J.C. van Loon and
G.A. Brooks. Univ. of California, Berkeley, Lawrence Berkeley
Natl. Lab. and Maastricht Univ., Netherlands.
WEDNESDAY PHYSIOLOGY
434
W533
1213.3 Building better animal models of disease
through integration of multiple disease phenotypes.
M.R.
Dwinell, R. Nigam, W. Liu, J.R. Smith, J. De Pons and M.
Shimoyama. Med. Col. of Wisconsin.
W534
1213.4 Metabolic profile assessment in offspring of
Wistar rats treated during pregnancy and lactation with sodium
selenite.
G.E.G. Kluck, R.L. Melo, G.E. Império, L.C. Reis and
W.S. Cortes. Fed. Rural Univ. of Rio de Janeiro, Seropédica.
1214. CONTROL OF BREATHING: CENTRAL
CONNECTIVITY, NEUROMODULATION AND
NEUROTRANSMISSION
Poster
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W535
1214.1 The effect of tracheal occlusion on the
load compensation response and the changes in inhibitory
neurotransmitter in the brainstem of conscious rats.
H-W. Tsai,
J. Condrey, S. Adams and P.W. Davenport. Univ. of Florida.
W536
1214.2 Ventral respiratory column tonic expiratory
neurons: nodes for convergent afferent modulation of inspiratory
drive.
L.S. Segers, S.C. Nuding, M.M. Ott, J.B. Dean, D.C.
Bolser, R. O’Connor, K.F. Morris and B.G. Lindsey. Univ. of
South Florida Morsani Col. of Med. and Univ. of Florida Col. of
Vet. Med.
W537
1214.3 Ventral respiratory column neuron interactions
and discharge patterns during expression of low-frequency
or very low-frequency brainstem network oscillations.
R.E.
O’Connor, S.C. Nuding, L.S. Segers, M.M. Ott, B.G. Lindsey
and K.F. Morris. Univ. of South Florida.
W538
1214.4 Effects of IV remifentanil on the discharge of
canine pontine respiratory group neurons in the parabrachial
complex.
I. Prkic, S. Mustapic, T. Radocaj, A.G. Stucke, E.A.
Stuth, F.A. Hopp and E.J. Zuperku. Med. Col. of Wisconsin,
Children’s Hosp. of Wisconsin and Zablocki VA Med. Ctr.
W539
1214.5 Altered glutamate receptor expression
following carotid body denervation in goats.
J.R. Miller, S.
Neumueller, C. Muere, S. Olesiak, L.G. Pan, M.R. Hodges
and H.V. Forster. Med. Col. of Wisconsin and VA Med. Ctr.
W540
1214.6 Microdialysis of a NK1R antagonist into the
ventral medulla does not affect breathing frequency.
C. Muere,
J. Miller, S. Neumueller, S. Olesiak, G. Mouradian, P. Martino,
L. Pan, M. Hodges and H. Forster. Med. Col. of Wisconsin,
Carthage Col., Marquette Univ. and Zablocki VA Med. Ctr.
W541
1214.7 Immunohistochemical changes in 5 respiratory
nuclei after bilateral carotid body denervation in Sprague
Dawley rats.
G.C. Mouradian, B.V. Forster and M.R. Hodges.
Med. Col. of Wisconsin.
W542
1214.8 Norepinephrine reconfigures post-inspiratory
neurons within the pre-Bötzinger complex of mice.
A. Garcia,
M.A. Khuu and J.M. Ramirez. Seattle Children’s Res. Inst. and
Univ. of Washington.
W543
1214.9 The horizontal brainstem slice: a novel
preparation to study cellular interactions of respiratory
rhythmogenesis.
T. Anderson, A.J. Garcia III and J-M.
Ramirez. Seattle Children’s Res. Inst. and Univ. of Washington.
W544
1214.10 KCNQ channels regulate activity of
chemosensitive neurons in the retrotrapezoid nucleus.
J.M.
Hawryluk, I.C. Wenker, A.C. Takakura, T.S. Moreira, A.V.
Tzingounis and D.K. Mulkey. Univ. of Connecticut and Univ.
of São Paulo.
W545
1214.11 HCN channels contribute to serotonergic
modulation of chemoreceptors in the retrotrapezoid nucleus.
V.
Hawkins, J. Hawryluk, A. Takakura, D. Williams, T. Moreira,
A. Tzingounis and D. Mulkey. Univ. of Connecticut and Univ.
of São Paulo.
W546
1214.12 Modulation of BK
Ca
channel activities by
calcium sensing receptor in rat bronchopulmonary sensory
neurons.
Z. Vysotskaya, C. Gilbert and Q. Gu. Mercer Univ.
Sch. of Med.
1215. LUNG PHYSIOLOGY: AIRWAY EPITHELIAL
CELL BIOLOGY
Poster
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W547
1215.1 LPS increase of ciliary beat frequency in
respiratory ciliated cells.
D.V. Carreno, C. Llados, M. Rios, N.
Cohen and M. Villalon. Pontifical Catholic Univ. of Chile and
Hosp. of Univ. of Pennsylvania.
W548
1215.2 IL-22 increases CFTR expression and host
defense capacity of airway epithelial cells.
E.A. Cowley, C.
Jones and T. Li. Dalhousie Univ., Canada.
W549
1215.3 Bicarbonate permeability of porcine bronchial
epithelium.
S.T. Ballard, J. Walker and M.I. Townsley. Univ. of
South Alabama.
W550
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