W.
Kaelin. Dana-Farber Cancer Inst.
9:30
Targeting HIF hydroxylases in inflammatory disease.
C.
Taylor. University Col. Dublin Conway Inst.
162. TRANSLATIONAL RESEARCH IN KIDNEY
DISEASE, HYPERTENSION AND ELECTROLYTE
DISORDERS
Featured Topic
(Sponsored by: APS Water and Electrolyte Homeostasis
and Renal Sections)
s
un
. 8:00
am
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8:00
Addicted to drugs: how side effects illuminate renal
physiology.
D. E. Ellison. Oregon Hlth. & Sci. Univ.
8:30
Insights into cAMP signaling in polycystic kidney
disease from depletion and interaction studies of
phosphodiesterase 1A and polycystin 2 in zebrafish.
C.R. Sussman, C.J. Ward, A.C. Leightner, P.C.
Harris and V.E. Torres. Mayo Clin. (910.6)
8:45
Curcumin and analog 2a inhibit
b-catenin pathway and
ADPKD cyst growth.
E. Bello-Reuss, R.L. Bacallao,
B-S. Herbert and M. Lee. Texas Tech Univ. Hlth. Sci.
Ctr., Indiana Univ., Indianapolis and Hope Col., MI.
(910.19)
9:00 SPAK-independent activation of NCC in salt-
sensitive hypertension.
A.S. Terker, C-L. Yang, J.A.
McCormick, S. Rogers and D.H. Ellison. Oregon
Hlth. & Sci. Univ.
(910.3)
9:15
Macula densa NOS1 protects against acute kidney
injury mediated by primary cilia.
Y. Fu, Y. Lu, L.A.
Juncos, Y. Ge, J.S. Pollock, J. Wei, R.J. Roman, L.
Cheng and R. Liu. Univ. of Mississippi Med. Ctr. and
Georgia Hlth. Sci. Univ.
(910.8)
9:30
Renalase protects against cisplatin acute kidney injury
in mice.
G.V. Desir, L. Wang, H. Velazquez, G.
Moeckel and R. Safirstein. Yale Sch. of Med and VA
Connecticut Healthcare Syst. Yale Renji Hosp.
(910.7)
9:45
HIF-1alpha and AMPK interactions regulate cellular
hypoxia adaptation in the subtotal nephrectomy model
of CKD.
P. Singh, J. Satriano, H. Li and K. Hallows.
UCSD and VA San Diego Healthcare Syst. and Univ.
of Pittsburgh.
(910.10)
163. BIOENGINEERING OF REGENERATIVE
MEDICINE
Symposium
(Sponsored by: Biomedical Engineering Society)
s
un
. 10:30
am
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onvention
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anD
r. t
uan
10:30
Materials to control cell trafficking and fate.
D. Mooney.
Harvard Univ.
11:00 Engeineering human tissues.
G. Vunjak-Novakovic.
Columbia Univ.
11:30
Biophysical factors in regenerative medicine.
D. Kaplan.
Tufts Univ.
12:00 Stem cells and biomaterials for tissue regeneration.
R.
Tuan. Univ. of Pittsburgh Sch. of Med.
164. CLAUDE BERNARD DISTINGUISHED
LECTURESHIP OF THE APS TEACHING OF
PHYSIOLOGY SECTION
(Turning Technologies graciously provided the audience
repsonse equipment)
s
un
. 10:30
am
—B
oston
C
onvention
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, 205C
Education
Title: Confessions of a Converted Lecturer
Speaker: E. Mazur. Harvard Sch. of Engin. and Applied
Sci.
165. FISHING WITH FLIES, WORMS AND BACTERIA:
EMERGING MODELS FOR MAMMALIAN
MEMBRANE TRANSPORT AND TRAFFICKING
Symposium
(Sponsored by: The Physiological Society and the
Journal of Physiology)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 207
C
haired
: D. t. t
hWaites
anD
W. r. h
arvey
10:30 Structural insights into the mechanism of sodium
coupled neurotransmitter transporters.
A. Penmatsa.
Oregon Hlth. & Sci. Univ.
11:00
Transcriptional and functional regulation of the intestinal
peptide transporter PEPT1 in C. elegans.
B. Spanier.
Tech. Univ. of Munich.
11:30
Teleost fish models in membrane transport research.
T.
Verri. Univ. of Salento, Lecce, Italy.
12:00 Evolving concepts in phagocytosis.
L. M. Stuart.
Massachusetts Gen. Hosp., Harvard Med. Sch.
PHYSIOLOGY SUNDAY
47
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166. GENETICS AND PHARMACOGENOMICS OF
CARDIOVASCULAR AND RENAL DISEASES
Featured Topic
(Sponsored by: APS Physiological Genomics Group)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 209
C
haired
: B. W. J
oe
anD
a. W. C
oWley
, J
r
.
Translational Physiology
10:30 Progress on genome-based studies for blood pressure
and related cardiovascular diseases.
G. Ehret. Univ.
of Geneva.
10:55 Shroom3, a novel GWAS renal candidate, is essential
for glomerular barrier function.
N.C. Yeo, C. O’Meara,
M. Flister, M. Cliff, J. Lazar, B. Link and H.J. Jacob.
Med. Col. of Wisconsin.
(955.6)
11:10
Epistasis involving variations within noncoding elements
accounts for ‘missing heritability’ of two closely-linked
blood pressure loci.
H. Waghulde, R. Pillai, Y. Nie, K.
Gopalakrishnan, S. Kumarasamy, P. Farms, M.R.
Garrett, S. Atanur, T.J. Aitman and B. Joe. Univ. of
Toledo, Univ. of Mississippi Med. Ctr. and Imperial Col.
London.
(955.3)
11:25 Identification of Btg2 as a candidate gene for
hypertension in females.
M.J. Hoffman, B. Xiao,
L. Nunez, M. Flister and C. Moreno. Med. Col. of
Wisconsin.
(955.7)
11:40
Genetic variants in Arhgef11 promote kidney injury and
reduced renal function in Dahl S rats.
Z. Jia, Z. Guo,
A.C. Johnson and M.R. Garrett. Univ. of Mississippi
Med. Ctr.
(955.10)
11:55 Genome-wide genetics of inflammation and statin
therapy for CVD prevention.
D. I. Chasman. Brigham
and Women’s Hosp.
12:15
Comt rs4680 variant and cardiometabolic side-
effects in children treated with second-generation
antipsychotics.
A.T. Cote, C. Panagiotopoulos and
A.M. Devlin. Univ. of British Columbia. (955.1)
167. THE IMPACT OF PATHOGENS ON THE
VASCULATURE
Symposium
(Sponsored by: APS Cardiovascular Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 206a
C
haired
: K. s
toKes
anD
F. G
avins
Inflammation and Immune Responses
Translational Physiology
10:30 Microvascular responses in sepsis.
P. Kubes. Univ. of
Calgary.
11:00
Platelet-bacterial interactions: a role in vascular disease.
D. Cox. Royal Col. of Surgeons in Ireland.
11:30 Crosstalk of parasite and host mitochondria in
inflammatory Chagasic cardiomyopathy.
N. Garg.
Univ. of Texas Med. Branch.
12:00
Pathogen burden: implications in cardiovascular disease.
S. Epstein. MedStar Hlth. Res. Inst., Washington
Hosp. Ctr.
168. INFLAMMATION AND CARDIORESPIRATORY
CONTROL
Featured Topic
(Sponsored by: APS Respiration Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 211
C
haired
: F. p
oWell
Inflammation and Immune Responses
10:30 Inflammation and cardiorespiratory control: the role of
the vagus nerve.
J. F. Thayer. The Ohio State Univ.
11:00
Systemic inflammation impairs respiratory
chemoreflexes and plasticity.
A. Huxtable. Univ. of
Wisconsin-Madison.
11:30 Selective contribution of inflammation and oxidative
stress to the cardiorespiratory and carotid body
alterations following intermittent hypoxia.
R. Del Rio,
E.A. Moya and R. Iturriaga. Pontifical Catholic Univ.
of Chile, Santiago.
(721.1)
11:45 Arachidonic acid stimulates avian intrapulmonary
chemoreceptor discharge.
K.M. Petelle, J.A.
Migdalene and S.C. Hempleman. Northern Arizona
Univ.
(721.7)
12:00 Prenatal inflammation (amnionitis) impairs acute
respiratory response to hypoxia.
W. Zenebe, D.
Litvin, K. Balan, R. Martin and P. Kc. Case Western
Reserve Univ. and FDA, Laurel, MD.
(721.6)
12:15 Central expression of IL-1
b and cardioventilatory
uncoupling in a rodent model of sepsis.
Y-H. Hsieh,
D. Nethery, F. Jacono and T. Dick. Case Western
Reserve Univ. and Louis Stokes VA Med. Ctr.
(721.8)
169. MOLECULAR IMAGING FOR PHYSIOLOGICAL
UNDERSTANDING
Symposium
(Sponsored by: APS Cardiovascular Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 210a
C
haired
: a. J. s
inusas
anD
W. D
oBruCKi
Inflammation and Immune Responses
Translational Physiology
10:30 MR and optical imaging of myocardial injury.
M.
Nahrendorf. Massachusetts Gen. Hosp., Harvard
Med. Sch.
11:00 Targeted ultrasound imaging of the vasculature and
myocardium.
F. S. Villanueva. Univ. of Pittsburgh.
11:30 Radiotracer based imaging of angiogenesis: focus on
instrumentation.
W. L. Dobrucki. Univ. of Illinois at
Urbana-Champaign.
12:00
Imaging of inflammation and vascular remodeling.
M. M.
Sadeghi. VA Med. Ctr., West Haven.
SUNDAY PHYSIOLOGY
48
170. REGULATION OF ION TRANSPORT IN THE
ALDOSTERONE-SENSITIVE DISTAL NEPHRON
Featured Topic
(Sponsored by: APS Renal Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 208
C
haired
: a. s
tarusChenKo
anD
D. e. K
ohan
Transporters and Ion Channels
10:30 Mechanisms of ENaC regulation in the aldosterone-
sensitive distal nephron.
A. Staruschenko. Med. Col.
of Wisconsin.
11:00 Src-family protein tyrosine kinase (SFK)
stimulatesKCNJ10 K channels in the basolateral
membrane of distal convoluted tubules.
W-H. Wang,
C-B. Zhang, D-H. Lin, P. Yue, L. Wang and J.
Rinehart. New York Med. Col. and Yale Univ. (911.1)
11:15
Kelch-like 3 (KLHL3) controls WNK4 ubiquitination and
degradation.
J-B. Peng and G. Wu. Univ. of Alabama
at Birmingham.
(911.14)
11:30 Active ENaC channels are selectively recycled.
R.S.
Edinger, M.B. Butterworth and J.P. Johnson. Univ.
of Pittsburgh.
(911.10)
11:45 Adenylyl cyclase VI is necessary for AVP stimulation
of ENaC.
V. Bugay, E. Mironova, K. Roos, N.
Ramkumar, D. Kohan and J. Stockand. Univ. of
Texas Hlth. Sci. Ctr. at San Antonio and Univ. of Utah
Hlth. Sci. Ctr.
(911.3)
12:00 Salt-dependent inhibition of the epithelial sodium
channel by bradykinin.
M. Mamenko, O.L. Zaika, P.A.
Doris and O. Pochynyuk. Univ. of Texas Hlth. Sci. Ctr.
at Houston.
(911.5)
12:15
Effect of nonpeptide V2 receptor antagonist SR121463
on phosphoproteome of rat IMCD.
J.L. Wilson, J.D.
Hoffert, T. Pisitkun and M.A. Knepper. NHLBI, NIH.
(911.6)
171. SLC26 TRANSPORTERS IN EPITHELIAL
SECRETION
Symposium
(Sponsored by: APS Cell and Molecular Physiology
Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 205B
C
haired
: s. m
uallem
anD
v. v
enGloveCz
Transporters and Ion Channels
10:30 Chair’s introduction.
V. Venglovecz. Univ. of Szeged,
Hungary.
10:35 Slc26a4 in shaping the vestibular aqueduct and in
hearing.
P. Wangemann. Kansas State Univ.
11:04 Slc26a3 and Slc26a6 in uterine bicarbonate secretion
and sperm capacitation.
H. C. Chen. Chinese Univ. of
Hong Kong.
11:33 Role of Slc26 transporters in oxalate homeostasis.
P.
Aronson. Yale Univ.
12:02 The Slc26 transporters and CFTR in synergism in
epithelial secretion.
S. Muallem. NIDCR, NIH.
172. SYMPATHETIC ACTIVITY IN BLOOD PRESSURE
REGULATION: SODIUM AND HORMONAL
MECHANISMS
Featured Topic
(Sponsored by: APS Central Nervous System Section)
s
un
. 10:30
am
—B
oston
C
onvention
& e
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C
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, 206B
C
haired
: G. F
inK
Blood Pressure Regulation
Central Control of Homeostasis
10:30 Activation of CNS aldosterone-MR-ENaC-ouabain
pathway by high salt intake.
F. Leenen. Univ. of
Ottawa Heart Inst.
11:00 Central osmosensory mechanisms in salt-sensitive
hypertension.
S. D. Stocker. Penn State Col. of Med.
11:30 Norepinephrine mediated sympathetic over-activity:
the relationship to sodium homeostasis and blood
pressure regulation.
R.D. Wainford and J.T.
Kuwabara. Boston Univ. (695.10)
11:45 Heart rate variability is altered by dietary sodium: a
randomized cross-over study in healthy young adults.
A.R. Allen, L.R. Gullixson, S.C. Wolhart, S.L. Kost,
D.R. Schroeder and J.H. Eisenach. Mayo Clin.
(695.17)
12:00
Intra-vital FRET imaging reveals enhanced sympathetic
arterial tone in angiotensin II-infused biosensor mice.
Y. Wang, L. Chen, W.G. Wier and J. Zhang. Univ. of
Maryland Sch. of Med.
(695.14)
12:15 Either sodium deprivation or sodium excess sensitizes
angiotensin II-induced hypertension.
B. Xue, Z.
Zhang, T. Beltz, F. Guo and A.K. Johnson. Univ. of
Iowa.
(695.12)
173. HUGH DAVSON DISTINGUISHED LECTURESHIP
OF THE APS CELL AND MOLECULAR
PHYSIOLOGY SECTION
s
un
. 2:00
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 210a
Title: Insulin Ssignal Transduction Meets Vesicle Traffic
via Rab GTPases and Unconventional Myosins
Speaker: A. Klip. The Hosp. for Sick Children, Toronto.
174. BIOLOGY EDUCATION: INCENTIVES AND
STRATEGIES FOR CHANGE
Symposium
(Sponsored by: APS Teaching of Physiology Section)
s
un
. 3:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 207
C
haired
: s. s
tavrianeas
anD
v. m
C
C
leary
Education
3:15
Partnerships for Undergraduate Life Science Education
(PULSE).
C. Sullivan. NSF.
3:30
Strategies to implement vision and change by the
Northwest Biosciences Consortium.
S. Stavrianeas.
Willamette Univ.
PHYSIOLOGY SUNDAY
49
S
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3:45
Changes underway at the University of North Dakota.
V. McCleary. Univ. of North Dakota Sch. of Med. and
Hlth. Sci.
4:00
Curriculum changes underway at Mercy College of
Health Sciences.
J. Matz. Mercy Col. of Hlth. Sci.
4:15 National Experiment in Undergraduate Science
Education (NEXUS): Developing interdisciplinary
competency-based curricula.
C. Bauerle. HHMI,
Chevy Chase.
175. ERNEST H. STARLING DISTINGUISHED
LECTURESHIP OF THE APS WATER AND
ELECTROLYTE HOMEOSTASIS SECTION
s
un
. 4:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 210a
Title: Collecting Duct Endothelium: The Last Word in
Sodium and Water Excretion and Blood Pressure
Regulation
Speaker: D. E. Kohan. Univ. of Utah Hlth. Sci. Ctr.
176. MICROCIRCULATORY SOCIETY LANDIS
AWARD LECTURE
s
un
. 3:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 205C
Title: Regulation of the Coronary Microcirculation: An
Evolution of Concepts and Importance
Speaker: W. M. Chilian. Northeast Ohio Med. Univ.
177. MITOCHONDRIAL DYNAMICS AND TURNOVER
WITH EXERCISE
Symposium
(Sponsored by: APS Environmental and Exercise
Physiology Section)
s
un
. 3:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 206a
C
haired
: D. a. h
ooD
3:15
Origins and current state of the muscle mitochondrial
reticulum.
G. A. Brooks. Univ. of California, Berkeley.
3:45
Mitochondrial fusion proteins in muscle: effects of
exercise and disease.
A. Zorzano. Univ. of Barcelona
and IRB Barcelona.
4:15
Fission and fusion of mitochondria: impact on mtDNA in
muscle.
D. C. Chan. Caltech.
4:45
Mitochondrial remodeling and mitophagy: implications
in exercise and muscle homeostasis.
M. Sandri. Univ.
of Padua.
178. MITOCHONDRIAL PHOSPHOLIPIDS,
ALDEHYDES, AND PROTEIN CARBONYLS:
AN EVALUATION OF THE GOOD, SOMETIMES
GOOD, AND UGLY CONSEQUENCES OF
DIETARY PUFAS
Symposium
(Sponsored by: APS Endocrinology and Metabolism
Section)
s
un
. 3:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 209
C
haired
: e. J. a
nDerson
anD
W. C. s
tanley
Metabolic Diseases
3:15
Oxidative stress and covalent modification of adipocyte
proteins with bioactive aldehydes.
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