1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

S.D. Emr, N. 

Buchkovich and M.M. Henne. Cornell Univ.

4:55  

Polarized release of TCR-enriched 

microvesicles at the center of the T cell immunological synapse.

 

M. Dustin. NYU Sch. of Med. (553.24)

5:10 

 

Landscape of the PARKIN-dependent ubiquitin 

modified proteome in response to mitochondrial depolarization 

defined through quantitative proteomics. 

S.A. Sarraf, M. 

Raman, V. Guarani-Pereira, M.E. Sowa, E.L. Huttlin, S.P. 

Gygi and J.W. Harper. Harvard Med. Sch. (553.17)

5:25 

212.3 

The ESCRT pathway in HIV budding and 

cytokinesis. 

W.I. Sundquist. Univ. of Utah.

5:50 

 

Discussion and closing remarks.

213.  CONTROLLING CELLULAR COMMUNICATION

Symposium

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3:45 

 

Chair’s introduction.

3:50 

213.1 

Disrupting bacterial communication to 

suppress multidrug resistant phenotypes. 

C. Melander. North 

Carolina State Univ.

4:15   

Structure activity relationship study of the 

cleistriosides and cleistetrosides for antibacterial/anticancer 

activity. 

P. Shi. Northeastern Univ. (1014.7)

4:30 

213.2 

Small molecules, toxins and cell death 

pathways. 

D.T. Hung. Harvard Med. Sch./Broad Inst./

Massachusetts Gen. Hosp.

4:55   

Single clone expression cloning and protein 

microarray platforms for novel extracellular receptor-ligand 

identification. 

I. Tom, G. Quinones, A. Estevez, M. Paluch, K. 

Bowman, Y. Franke, K. Billeci, P. Hass, J. Tang, N. Lewin-

Koh, D. Eaton, J-P. Stephan and L. Gonzalez. Genentech. 

(803.5)

5:10   

A small optogenetic tool for spatiotemporal 

control of intracellular cAMP. 

C.P. O’Banion and D.S. 

Lawrence. Univ. of North Carolina at Chapel Hill. (566.1)

5:25 

213.3 

Signals from the surface to control cell fate 

decisions. 

L.L. Kiessling. Univ. of Wisconsin-Madison.

5:50 

 

Discussion and closing remarks.

BIOCHEMISTRY MONDAY

57

M

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214.  BACK TO BASICS: THE BIOLOGY OF BREAST 

CANCER

Symposium

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3:45 

 

Chair’s introduction.

3:50 

214.1 

Exosomal media enhances proliferation, 

migration, and invasion in triple negative breast cancer. 

K. 

Parker Johnson, D.C. Stoute, L. Yearby, G. Beverly, E. 

Skripnikova and J. Ochieng. Col. of Pharm., Xaiver Univ. of 

LA and Meharry Med. Col.

4:15   

The green tea polyphenol EGCG induces 

mesenchymal to epithelial transition and tumor regression in 

triple negative breast cancer cells and mouse-xenograft model: 

involvement of CCN5. 

A. Das, S. Banerjee, A. De, I. Haque, G. 

Maity, M. McEwen and S.K. Banerjee. VA Med. Ctr., Kansas 

City, MO and Univ. of Kansas Med. Sch. 

(610.2)

4:30 

214.2 

Novel targets in advanced breast cancer in 

African American patients. 

S. Ambs. NCI, NIH.

4:55   

ADAM12: a novel mediator of tumor 

angiogenesis. 

R. Roy and M. Moses. Boston Children’s Hosp. 

and Harvard Med. Sch. 

(609.1)

5:10   

Novel strategy for lineage tracing of cancer 

stem cells. 

T.M. Nguyen, E.C. Chang and J.M. Rosen. 

Wabash Col. and Baylor Col. of Med. 

(609.2)

5:25 

214.3 

High risk CNIs, race and early stage breast 

cancer. 

P.A. Thompson, A. Brewster, K-A. Do, A.A. Sahin, 

G. Mills and M. Bondy. Univ. of Arizona Cancer Ctr., Univ. of 

Texas MD Anderson Cancer Ctr. and Baylor Col. of Med.

5:50 

 

Discussion and closing remarks.

215.  TRAINING FOR A WORLD IN TRANSITION

Symposium

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ennelly

3:45 

 

Chair’s introduction.

3:50 

215.1 

Developing the nation’s human capital in STEM 

for tomorrow. 

J. Ferrini-Mundy. Natl. Sci. Fndn.

4:15 

A metabolic pathways diagnosis test for assessing the 

development of biochemistry students’ visualization skills. 

E. 

Galembeck, V.J.S.V. dos Santos and T. Anderson. UNICAMP, 

Campinas, Brazil, Purdue Univ. and Fed. Univ. of São João, 

Brazil. 

(838.5)

4:30 

215.2 

Ramping up for STEM success: new models 

for transfer. 

S. Albertine. Assn. of Amer. Cols. And Univs., 

Washington, DC.

4:55 

 

Developing a robust POGIL model to connect 

basic biochemistry to the physiological changes during 

starvation. 

D. Dean and E. Anderson. Univ. of Saint Joseph, 

CT. 

(613.3)

5:10   

An inexplicable disease—prion disease as 

a ‘choose-your-own-experiment’ case to introduce students 

to scientific inquiry. 

J.K. Hines, A. Serrano and S. Miller. 

Lafayette Col., PA and Univ. of Wisconsin-Madison. 

(612.3)

5:25 

215.3 

Educating students for an interdisciplinary 

world. 

L.A. Kuhn. Michigan State Univ.

5:50 

 

Discussion and closing remarks.

216.  ASBMB THEMATIC FERMENTATION HOUR

Special Event

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Join fellow biochemists and molecular biologists for 

continued scientific discussion following the afternoon sessions. 

Enjoy a cool beverage and casual atmosphere.

217.  ASBMB SCIENCE CAFÉ: THE NEW SOCIAL 

NETWORKING EVENT

Special Event

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pm

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aterFront

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otel

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s

auCiety

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estaurant

Ever wondered where in the universe another Earth-like 

planet might be?  What would such a planet look like?  Is there 

the possibility of life?  Join us for a discussion of these and 

other fascinating questions at the ASBMB Science Café with 

C. 

Dressing, Harvard-Smithsonian Ctr. for Astrophysics.

Experimental Biology exhibitors offer the best tools and  

resources available in research today!

Join the exhibitors at 10:00 

am

 for coffee and 2:00 

pm

 for snacks and  

learn the latest and greatest from more than 300 companies.

MONDAY BIOCHEMISTRY

58

Nutrition

220.  THE WORLD HAS CHANGED AND SO MUST 

YOUR COMMUNICATION STYLE

Symposium

(Sponsored by: Public Information Committee and the 

Public Policy Committee)

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azzaniGa

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Education Track/Professional Development

Career Development

8:00 Introduction.

8:15 

The new world of nutrition science communications. 

C. 

Kapica. The Awegrin Inst.

8:50 

Techniques for getting to the point in 3 minutes or less. 

M. McGuire. Washington State Univ.

9:25 

Techniques for getting to the point in 3 minutes or less. 

L. Troy. Univ. of Massachusetts Amherst.

221.  FOOD ENVIRONMENT AND POLICY

Minisymposium

(Sponsored by: Community and Public Health Nutrition RIS)

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eane

8:00 

221.1 

Improving access in food deserts: a case 

study in an urban midwestern neighborhood. 

C.A. Gibson, D. 

Endicott and C.C. Pritchard. Univ. of Kansas Med. Ctr. and 

Good Natured Family Farms, Kansas City.

8:15 

221.2 

The energy content of restaurant foods without 

stated calorie information. 

L.E. Urban, A.H. Lichtenstein, C.E. 

Gary, J.L. Fierstein, A. Equi, C. Kussmaul, G.E. Dallal and 

S.B. Roberts. USDA at Tufts Univ.

8:30 

221.3 

Where do children get food? Building a 

searchable, visual database of food sources through ground-

truthing. 

H. Coakley, A. Zablotny, Y.S. Cheah, Y. Mui, E.A. 

Steeves, G. Glass, A. Hackman, M. Sherman and J. 

Gittelsohn. Johns Hopkins Bloomberg Sch. of Publ. Hlth.

8:45 

221.4 

Impact of national policy banning TV 

advertisement on high-energy/low-nutrient foods. 

S-K. Lee, 

S-Y. Nam, B.J. Yoon and S-J. Chung. Inha Univ., Seoul Natl. 

Univ. and Kookmin Univ., South Korea.

9:00 

221.5 

Do front-of-pack nutrition rating systems and 

symbols (FOPS) direct consumers to the healthiest products in 

an unregulated environment? 

T. Emrich and M. L’Abbe. Univ. 

of Toronto.

9:15 

221.6 

Adaptation of the Nutrition Environment 

Measures Survey-Stores to assess a Mexican/Mexican-

American nutrition environment. 

D.M. Winham and S. 

Szkupinski Quiroga. Howell Res. Assocs LLC, Queen Creek, 

AZ and Arizona State Univ.

218.  SEARCHING FOR THE EVIDENCE THAT 

LINOLEIC ACID FUELS INFLAMMATION

Symposium

(Sponsored by: Medical Nutrition Council)

(Supported by an educational grant from The Beef 

Checkoff)

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am

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oston

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onvention

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B

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elury

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oChaired

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inley

Nutrition and Inflammation

8:00  Does linoleic acid fuel inflammation? The pro 

perspective. 

C. Ramsden. U.S. Publ. HHh. Svc.

8:30 

Linoleic acid and inflammation: a hypothesis without 

fuel. 

W. C Willett. Harvard Sch. of Publ. Hlth.

9:00 

Putting out the fire: evidence that linoleic acid-rich 

vegetable oils have anti-inflammatory effects. 

M. A. 

Belury. The Ohio State Univ.

9:30 

New innovations in “designer” vegetable oils – less 

PUFA and SFA, and more MUFA. Are there health 

benefits? 

P. M. Kris-Etherton. Penn State.

219.  GLOBAL PERSPECTIVES ON PRETERM 

BIRTH AND FETAL GROWTH RESTRICTION: 

MATERNAL AND NUTRITIONAL INFLUENCES

Symposium

(Sponsored by: Global Nutrition Council)

(Supported by an educational grant from CHERG with the 

Support of the Bill and Melinda Gates Foundation)

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laCK

Pediatric Nutrition and Early Development

8:00 

Introductory comments. 

R. Black. Johns Hopkins Univ. 

Bloomberg Sch. of Publ. Hlth.

8:05 

Contribution of preterm birth and FGR to infant mortality –  

global and regional disease burden estimates. 

J. 

Katz. Johns Hopkins Univ. Bloomberg Sch. of Publ. 

Hlth.

8:25 

Contributions of preterm birth and FGR to childhood 

undernutrition. 

P. Christian. Johns Hopkins Univ. 

Bloomberg Sch. of Publ. Hlth.

8:45 

Maternal nutrition and other risk factors of preterm birth 

and FGR. 

A. C. Lee. Brigham and Women’s Hosp.

9:05 

RCT of antenatal vitamin A and zinc and birth outcomes 

in Tanzania – mechanisms related to angiogenesis. 

W. Fawzi. Harvard Sch. of Publ. Hlth.

9:25 

RCT of antenatal micronutrients and endocrine and fetal 

growth factors in Bangladesh. 

A. Gernand. Univ. of 

Pittsburgh.

9:45 Q&A.

NUTRITION MONDAY

59

M

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9:30 

221.7 

Modeling the impact of revisions to daily values 

assuming that current % daily values in fortified foods are 

maintained. 

M.M. Murphy, J.H. Spungen, L.M. Barraj, R.L. 

Bailey and J. Dwyer. Exponent Inc., Washington, DC, ODS, 

NIH and USDA and Sch. of Med., Tufts Univ.

9:45 

221.8 

How does household composition affect 

purchases of grain-based desserts? 

K.C. Mathias, S.W. Ng 

and B.M. Popkin. Univ. of North Carolina at Chapel Hill.

222.  NUTRIENT-GENE INTERACTIONS: LIPIDS

Minisymposium

(Sponsored by: Nutrient-Gene Interactions RIS)

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8:00 

222.1 

Interaction effects between n-3 polyunsaturated 

fatty acids and genetic variations in genes involved in de 

novo lipogenesis on plasma triglyceride levels. 

A. Bouchard-

Mercier, I. Rudkowska, S. Lemieux, P. Couture and M-C. 

Vohl. Laval Univ., Canada.

8:15 

222.2 

Creatine supplementation may prevent NAFLD 

by stimulating fatty acid oxidation. 

R.L. Jacobs, R. da Silva 

and R. Nelson. Univ. of Alberta.

8:30 

222.3 

Specificity factor 1 mediates transcriptional 

induction of Atp7a during hypoxia in rat intestinal epithelial 

(IEC-6) cells. 

L. Xie and J.F. Collins. Univ. of Florida.

8:45 

222.4 

Genome-wide contribution of genotype by 

environment interaction to blood lipid variation. 

C-Q. Lai, D.K. 

Arnett, K. Richardson, L.D. Parnell, I.B. Borecki and J.M. 

Ordovas. USDA at Tufts Univ., Univ. of Alabama at Birmingham 

and Washington Univ. Sch. of Med.

9:00 

222.5 

Clock 3111 T/C SNP interacts with saturated 

fatty acid intake to modulate plasma LDL-C concentrations 

in the Boston-Puerto Rican Health Study. 

H.S. Dashti, K.L. 

Tucker, C.E. Smith, Y. Ma, Y-C. Lee and J.M. Ordovás. USDA 

at Tufts Univ. and Northeastern Univ.

9:15 

222.6 

Gamma-tocotrienol antagonizes adipogenesis 

through activation of AMPK/autophagy axis in primary human 

adipocytes. 

L. Zhao, J-H. Ha, I. Kang, M. Okla and S. Chung. 

Univ. of Florida.

9:30 

222.7 

Gene-dietary fat interaction and bone mineral 

density in children: a twin study in China. 

T. Huang, W. Zhao, 

H. Liu and Y. Wang. Johns Hopkins Univ. and Jiaxing Maternity 

and Children Hlth. Care Hosp., China.

9:45 

222.8 

Gene and nutrient interaction in obesity: 

trans fatty acid intake and genetic risk score interaction in 

a multiethnic sample of children. 

M.M. Bohan Brown, M. 

Rodriguez-Cruz and J.R. Fernandez. Univ. of Alabama at 

Birmingham and Mexican Soc. Security Inst., Mexico City.

223.  IRON, COPPER AND CHRONIC DISEASE

Minisymposium

(Sponsored by: Vitamins and Minerals RIS)

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Wain

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alaCios

8:00 

223.1 

Weight, serum hepcidin, and iron status in 

pregnant African American women. 

L. Tussing-Humphreys, 

R. White-Traut and M.D. Hennessy. Univ. of Illinois at Chicago.

8:15 

223.2 

Placental expression of the heme scavenger 

receptor, LDL receptor-related protein 1, is associated with 

expression of placental heme exporter, feline leukemia virus C 

receptor 1. 

C. Cao, E. Cooper, E. Pressman, R. Guillet and 

K.O. O’Brien. Cornell Univ. and Univ. of Rochester Sch. of 

Med.

8:30 

223.3 

Improvement of the intestinal Caco-2 cell 

model for iron absorption studies by the introduction of liver 

(HepG2) cells. 

N.M. Scheers, A. Almgren and A-S. Sandberg. 

Chalmers Univ. of Technol., Sweden.

8:45 

223.4 

Plasma and liver lipids of iron-deficient rats 

with excessive dietary manganese. 

K. Yokoi, A. Konomi, I. 

Tachibana and Y. Uchida. Seitoku Univ. and Teikyo Heisei 

Univ., Japan.

9:00 

223.5 

Silencing of the Menkes copper-transporting 

ATPase (ATP7a) in intestinal epithelial cells impairs cell growth 

and cell cycle control. 

S. Gulec and J.F. Collins. Univ. of 

Florida.

9:15 

223.6 

The small molecule genistein increases 

hepcidin expression by activating Stat3 and bone morphogenic 

protein signaling. 

P.G. Fraenkel, A.W. Zhen, N.H. Nguyen, Y. 

Gibert, S. Motola, P. Buckett, M. Wessling-Resnick and E. 

Fraenkel. Beth Israel Deaconess Med. Ctr./Harvard Med. Sch., 

Deakin Sch. of Med., Australia, MIT and Harvard Sch. of Publ. 

Hlth.

9:30 

223.7 

Effects of the iron transporter inhibitor ferristatin 

II on serum iron and lipid metabolism. 

J. Kim, P. Buckett and 

M. Wessling-Resnick. Harvard Sch. of Publ. Hlth.

9:45 

223.8 

Status of selected iron-status biomarkers in 

juvenile end-stage renal disease in a Guatemalan context: 

comparative aspects by mode of dialysis. 

J. Casimiro, R. 

Lou-Meda, M. Olbert, G. Weiss, D.W. Swinkels, H. Tjalsma, 

N.W. Solomons and K. Schümann. Tech Univ. Munich, Hosp. 

Roosevelt, Guatemala City, MBR Optical Systs., Wuppertal, 

Germany, Med. Univ. of Innsbruck, Radboud Univ. Nijmegen 

Med. Ctr., Netherlands and CeSSIAM, Guatemala City.

MONDAY NUTRITION

60

224.  EFFECTS OF DIETARY BIOACTIVE 

COMPONENTS ON EXPERIMENTAL MODELS 

OF CHRONIC DISEASE RISK

Minisymposium

(Sponsored by: Dietary Bioactive Components RIS)

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eilson

8:00