1. The pathophysiology of anaphylaxis

Allergen:

• Allergen:

• IgE + Ag Mast cells, basophils:
• Histamin, triptase, leukotriens, eosinophilic chemotactic factors are released.
• IgG leads to “complemant” system activation.

• Non-Allergic (non-IgE, non-immun):

• Reaction is developed by means of direct pharmacologic, toxic stimulus of the mast cells & basophils; Inflammatory mediators are released.

An identical or very similar clinical response (skin reaction) which is not mediated by IgE, or an Antigen-Antibody process.

• An identical or very similar clinical response (skin reaction) which is not mediated by IgE, or an Antigen-Antibody process.