1. The pathophysiology of anaphylaxis

Anaphylaxis incidence during anesthesia is: 1/5.000-1/20.000

• Anaphylaxis incidence during anesthesia is: 1/5.000-1/20.000

• Multiple drug use duing general anesthesia may mask the symptoms.

• Diagnosis during anesthesia is DIFFICULT !

Non-depolarizing neuromuscular blockers

• Non-depolarizing neuromuscular blockers

• Latex & antibiotics

• Colloid solutions, barbituric acid

• All drugs & agents used during surgery or anesthesia may be responsible

• Mind the solutions or drugs used by the SURGEON !!

Topical, infiltration Local Anesthetic agents (<%1 anaphylaxis)

• Topical, infiltration Local Anesthetic agents (<%1 anaphylaxis)

• Irrigation solutions

• Latex

• Disinfectant

• Markers (patent blue)