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Immunodeficiency
Immunodeficiency refers to a state in which the immune
system’s ability to fight infectious disease is compromised
or entirely absent. Immunodeficiency disorders
may result from a primary genetic defect (primary
immunodeficiency—see Primary Immunodeficiency
article in this supplement) which can effect either innate
or acquired immune function through inhibition of
selected immune cells or pathways, or it may be acquired
from a secondary cause (secondary immunodeficiency),
such as viral or bacterial infections, malnutrition,
autoimmunity or treatment with drugs that induce
immunosuppression. Certain diseases can also directly
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