Appendix 1 medline search strategy exp arthritis, rheumatoid/ 2

Appendix 1

MEDLINE search strategy

1. exp arthritis, rheumatoid/

2. ((rheumatoid or rheumatoid or revmatoid or rheumatic or rheumatic or revmatic or rheumat$ or reumat$ or revmarthrit$) adj3 (arthrit$ or artrit$ or condition$ or nodule$)). tw.

3. 1or 2

4. exp PROBIOTICS/tu or probiotic$.tw. 

5. exp LACTOBACILLUS/ or lactobacill$.tw. or "l acidophilus".tw. or "l casei".tw. or bifidobacter$.mp. or "b infantis".tw. or "b bifidum".tw. or "b longum".tw. or saccharomyce$.mp. or "s boulardii".tw. or clostridium butyricum.tw. or clostridium difficile.mp. or "streptococcus thermophilus".tw. or enterococcus faecium.mp.

6. exp antibiosis/ or biotherapeutic agent$.tw.

7. or/4-6 

8. random$.tw. 

9. factorial$.tw. 

10. (crossover$ or cross over$ or cross-over$).tw.

11. placebo$.tw. 

12. single blind.mp. 

13. double blind.mp. 

14. triple blind.mp. 

15. (singl$ adj blind$).tw.

16. (double$ adj blind$).tw. 

17. (tripl$ adj blind$).tw. 

18. assign$.tw. 

19. allocat$.tw. 

20. crossover procedure/ 

21. double blind procedure/

22. single blind procedure/, 

23. triple blind procedure/, 

24. randomized controlled trial/, 

25. or/8-24, 

26. (exp animal/ or animal.hw. or nonhuman/) not (exp human/ or human cell/ or (human or humans).ti.), 

27. 25 not 26, 

28. 3 and 7 and 27

[/=MeSH term, exp=explode, tw=text word, mp=multipurpose word, $=truncation]

EMBASE search strategy

1# rheumatoid arthritis/exp

2# ((rheumatoid OR rheumatoid OR revmatoid OR rheumatic OR rheumatic OR revmatic OR rheumat* OR reumat* OR revmarthrit*) NEAR/3 (arthrit* OR artrit* OR diseas* OR condition* OR nodule*))

3# 1 or 2

4# PROBIOTICS/exp OR probiotic*

5#  LACTOBACILLUS/exp OR lactobacill*OR "l acidophilus" OR "l casei" OR bifidobacter* OR "b infantis" OR "b bifidum" OR "b longum" OR saccharomyce* OR "s boulardii" OR clostridium butyricum OR clostridium difficile OR "streptococcus thermophilus" OR enterococcus faecium

6# antibiosis/exp OR biotherapeutic agent*

7# or/4-6 

8. random* 

9. factorial* 

10. (crossover* OR cross over* OR cross-over*)

11. placebo* 

12. single blind

13. double blind

14. triple blind

15. (singl* NEAR/2 blind*)

16. (double* NEAR/2 blind*) 

17. (tripl* NEAR/2 blind*) 

18. assign* 

19. allocate* 

20. crossover procedure 

21. double blind procedure

22. single blind procedure 

23. triple blind procedure 

24. randomized controlled trial 

25. or/8-24, 

26. (animal/exp OR animal OR nonhuman) NOT (human/exp OR human cell OR (human or humans)/ti) 

27. 25 not 26, 

28. 3 and 7 and 27

CENTRAL search strategy

ID Search Hits

#1 MeSH descriptor: [Arthritis, Rheumatoid] explode all trees

#2 ((rheumatoid or rheumatoid or revmatoid or rheumatic or rheumatic or revmatic or rheumat* or reumat* or revmarthrit*) near/3 (arthrit* or artrit* or diseas* or condition* or nodule*)):ti,ab

#3 #1 or #2

#4 MeSH descriptor: [Probiotics] explode all trees

#5 probiotics:ti,ab

#6 MeSH descriptor: [Lactobacillus] explode all trees

#7 lactobacill* or "l acidophilus" or "l casei" or bifidobacter* or "b infantis" or "b bifidum" or "b longum" or saccharomyce* or "s boulardii" or clostridium butyricum or clostridium difficile or "streptococcus thermophilus" or enterococcus faecium

#8 MeSH descriptor: [Antibiosis] explode all trees

#9 biotherapeutic agent*

#10 #9 or #8 or #7 or #6 or #5 or #4

#11 random

#12 factorial

#13 (crossover* or cross over* or cross-over*)

#14 placebo

#15 single blind

#16 double blind

#17 triple blind

#18 (singl* near/2 blind*)

#19 (double* near/2 blind*)

#20 (tripl* near/2 blind*)

#21 assign*

#22 allocat*

#23 crossover procedure

#24 double blind procedure

#25 single blind procedure

#26 triple blind procedure

#27 randomized controlled trial

#28 #27 or #26 or #25 or #24 or #23 or #22 or #21 or #20 or #19 or #18 or #17 or #16 or #15 or #14 or #13 or #12 or #11

#29 MeSH descriptor: [Animals] explode all trees

#30 (animal or nonhuman) not (human or human cell or (human or humans):ti)

#31 #28 not (#30 or #29)

#32 #31 and #10 and #3

Web of Science search strategy

TS=((rheumatoid or reumatoid or revmatoid or rheumatic or reumatic or revmatic or rheumat* or reumat* or revmarthrit*) and (arthrit* or artrit* or diseas* or condition* or nodule*)) AND Topic=(probiotic* or Lactobacillus or lactobacill* or "l acidophilus" or "l casei" or bifidobacter* or "b infantis" or "b bifidum" or "b longum" or saccharomyce* or "s boulardii" or clostridium butyricum or clostridium difficile or "streptococcus thermophilus" or enterococcus faecium or Antibiosis or biotherapeutic agent*)

(trial* or random* or placebo* or control* or double or treble or triple or blind* or mask* or allocat* or prospective* or volunteer*or comparative or evaluation or follow-up or followup)