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DISCLOSURE STATEMENT
The authors are not aware of any affiliations, memberships, funding, or financial holdings that
might be perceived as affecting the objectivity of this review.
ACKNOWLEDGMENTS
Due to the broad topical coverage in this review, citations are mostly focused on a selection of
recent original literature. We apologize to the authors of the many additional original studies not
cited here and the authors of older work for citing review articles instead. We thank Kevin Fidelin,
Manuel Ferreira-Pinto, and Rui Costa for their constructive comments on the manuscript. L.R.
and S.A. were supported by a European Research Council Advanced Grant (692617), the Swiss
National Science Foundation, the Kanton Basel-Stadt, the Novartis Research Foundation, and
the Louis Jeantet Prize for Medicine.
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