Description

DOSAGE AND ADMINISTRATION, Maintenance of Patency of Intravenous Devices for 
directions for use.) 
HEP-LOCK U/P is not to be used for anticoagulant therapy. 
CONTRAINDICATIONS 
Heparin sodium should NOT be used in patients with the following conditions: severe 
thrombocytopenia; an uncontrollable active bleeding state (see WARNINGS), except when this is due 
to disseminated intravascular coagulation. 
WARNINGS 
Heparin is not intended for intramuscular use. 

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NDA 17-037/S-158 
Page 25 
Hypersensitivity 
Patients with documented hypersensitivity to heparin should be given the drug only in clearly life-
threatening situations. (See ADVERSE REACTIONS, Hypersensitivity.) 
Hemorrhage 
Hemorrhage can occur at virtually any site in patients receiving heparin. An unexplained fall in 
hematocrit, fall in blood pressure or any other unexplained symptom should lead to serious 
consideration of a hemorrhagic event. 
Heparin sodium should be used with extreme caution in infants and in patients with disease states in 
which there is increased danger of hemorrhage. Some of the conditions in which increased danger of 
hemorrhage exists are: 
Cardiovascular 
Subacute bacterial endocarditis, severe hypertension. 
Surgical 
During and immediately following (a) spinal tap or spinal anesthesia or (b) major surgery, especially 
involving the brain, spinal cord or eye. 
Hematologic 
Conditions associated with increased bleeding tendencies, such as hemophilia, thrombocytopenia and 
some vascular purpuras. 
Gastrointestinal 
Ulcerative lesions and continuous tube drainage of the stomach or small intestine. 
Other 
Menstruation, liver disease with impaired hemostasis.