Description

Withdrawal Of Blood Samples 
Heparin Lock Flush Solution, USP may also be used after each withdrawal of blood for laboratory 
tests. When heparin would interfere with or alter the results of blood tests, the heparin solution should 
be cleared from the device by aspirating and discarding it before withdrawing the blood sample. 
HOW SUPPLIED 
HEP-LOCK (Heparin Lock Flush Solution, USP) 
10 USP units/mL 

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NDA 17-037/S-158 
Page 21 
1 mL DOSETTE vials packaged in 25s (NDC 0641-0392-25) 
2 mL DOSETTE vials packaged in 25s (NDC 0641-0393-25) 
10 mL Multiple Dose vials packaged in 25s (NDC 0641-2438-45) 
30 mL Multiple Dose vials packaged in 25s (NDC 0641-2442-45) 
100 USP units/mL 
1 mL DOSETTE vials packaged in 25s (NDC 0641-0389-25) 
2 mL DOSETTE vials packaged in 25s (NDC 0641-0387-25) 
10 mL Multiple Dose vials packaged in 25s (NDC 0641-2436-45) 
30 mL Multiple Dose vials packaged in 25s (NDC 0641-2443-45) 
Storage 
Store at 20
°-25°C (68°-77°F) [see USP Controlled Room Temperature]. 
REFERENCES 
1. Tahata T, Shigehito M, Kusuhara K, Ueda Y, et al. Delayed-Onset of Heparin Induced Thrombocytopenia – 
A Case Report – J Jpn Assn Torca Surg.1992;40(3):110-111. 
2. Warkentin T, Kelton J. Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis. Annals of 
Internal Medicine. 2001;135:502-506. 
3. Rice L, Attisha W, Drexler A, Francis J. Delayed-Onset Heparin Induced Thrombocytopenia. Annals of 
Internal Medicine, 2002;136:210-215. 
4. Dieck J., C. Rizo-Patron, et al. (1990). “A New Manifestation and Treatment Alternative for Heparin-
Induced Thrombosis.” Chest 98(1524-26). 
5. Smythe M, Stephens J, Mattson. Delayed-Onset Heparin Induced Thrombocytopenia. Annals of Emergency 
Medicine, 2005;45(4):417-419. 
6. Divgi A. (Reprint), Thumma S., Hari P., Friedman K., Delayed Onset Heparin-Induced Thrombocytopenia 
(HIT) Presenting After Undocumented Drug Exposure as Post-Angiography Pulmonary Embolism. Blood. 
2003;102(11):127b. 
Hep-Lock, Baxter and Dosette are registered trademarks of Baxter International, Inc., or its 
subsidiaries. 
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