Hellp syndrome may it be a separate entity?



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HELLP Syndrome


HELLP Syndrome

  • may it be a separate entity?



HELLP, a syndrome characterized by hemolysis, elevated liver enzyme levels and a low platelet count, is an obstetric complication that is frequently misdiagnosed at initial presentation. Many investigators consider the syndrome to be a variant of preeclampsia,

  • HELLP, a syndrome characterized by hemolysis, elevated liver enzyme levels and a low platelet count, is an obstetric complication that is frequently misdiagnosed at initial presentation. Many investigators consider the syndrome to be a variant of preeclampsia,





Epidemiology and Risk Factors

  • HELLP syndrome 0.2 to 0.6 % of all pregnancies.

  • Preeclampsia 5 to 7 % of all pregnancies.



Etiology and Pathogenesis

  • The hemolysis in HELLP syndrome is a microangiopathic hemolytic anemia. Red blood cells become fragmented as they pass through small blood vessels with endothelial damage and fibrin deposits.

  • The peripheral smear may reveal spherocytes, schistocytes, triangular cells and burr cells.


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