Organizing co mmittee

CHEMICAL COMPOSITION Ferula tadshikorum
OF THE FLORA OF UZBEKISTAN 
E.Kh. Khalilova, Kh.M. Bobakulov, S.F. Aripova
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
 
A number of resolutions of the President of the Republic of Uzbekistan noted "To 
ensure the development of technologies for the production of medicines necessary for 
medicine and agriculture by processing raw ferula". In light of this Decree, the goal is: 
based on chemical components, namely terpenoids of the 
Ferula
tadshikorum
plant of 
the flora of the Republic of Uzbekistan and the identified biological activity, the 
development of technology and preparation for the introduction of a number of effective 
medicines for medicine. 
F. tadshikorum
is a perennial, monocarpic, strongly and 
unpleasantly smelling herbaceous plant of the family – 
Apiaceae
(
Umbelliferae
).
 
Ferula tadshikorum
grows in Kashkadarya, Surkhandarya and other regions of the 
Republic of Uzbekistan. It is known from the literature that in the East, resin obtained 
from fresh ferula roots by cutting is used as a spice. Currently, industrial preparations of 
this resin, which is exported by tons as a spice to India, Iran, Pakistan, Afghanistan, lead 
to depletion of stocks of this plant. In folk medicine of the East, 
F. tadshikorum
is 
known to be used as an antiparasitic, antispasmodic, expectorant, for tuberculosis, 
syphilis, malignant tumors, to improve digestion and other properties.
 
The chemical composition of the aerial part of 
F. tadshikorum
collected in Surkhandarya 
region with 85% ethanol was studied. The condensed ethanol extract was fractionated according 
to solubility in various organic solvents (extraction benzene, chloroform, ethyl acetate). In the 
benzene extract of the aerial part of 
F. tadshikorum
were identified 8 compounds (54.4%) by GC-
MS analysis. The main components of the benzene extract were thiophene derivatives: 2,5-
dimethylthiophene (1.7%), 2,4-dimethylthiophene (7.9%), 3,4-dimethylthiophene (21.1%).
In order to identify the main components of 
F. tadshikorum
resin benzene extracts of 
7 samples from different collection regions were obtained. The presence of common 
chemical components (palmitic, oleic, palmitooleic, lauric, myristic acids, their esters, 

-bisabolene, 

-selinene and sulfur-containing components) was noted in all resin 
samples.
The macro- and microelement composition of the resin of the roots of the 
F. 
tadshikorum
plant was studied by mass spectrometry with inductively coupled argon 
plasma. The data obtained indicate the content of a large number of macro- and 
microelements (K, Ca, Mg, Zn, Fe, Ag) useful for a living organism in the resin. 
Thus, by studying the chemical composition of the aboveground part of 
F. 
tadshikorum
growing in the flora of Uzbekistan, it is shown that the main components in 
the plant are thiophene derivatives: 2,5-dimethylthiophene, 2,4-dimethylthiophene, 3,4-
dimethylthiophene, which can be used in the standardization of the substance obtained on 
the basis of this plant. The elemental composition of this plant was studied for the first 
time.

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Poster presentation 
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