Organizing co mmittee

SYNTHESIS OF NOVEL MONO-SUBSTITUTED TRIAZINE, 
CONTAINING A FARMACOPHORIC QUINAZOLINE RING 
 
F. A. Zulpanov,
1
 B. J. Elmuradov,
1
 D. M. Ruziboev,
1
B. A. Sobirov
2
, J. O‘. Muyassarov
3
 
 
1
) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
2) Mirzo Ulugbek
 
National University of Uzbekistan, Faculty of Chemistry 
3) Samarkand State University, University blv. 15, Samarkand 140104, Uzbekistan 
Triazine derivatives are widely used as weed control agents. Most of them are 
selective herbicides. At present, preparations based on metamitron and metribuzin are 
approved for use. For a long time, triazines (
atrazine
, 
simazine
, 
propazine
, 
promethrin
, 
ametrine
, etc.) occupied a leading position in terms of production and use in world 
agriculture and were very widely used in our country. Since 2007, 
atrazine
has not been 
included in the list of herbicides recommended for use, but in world practice it is still 
used in corn and sorghum crops. 
Derivatives of 
sim
-triazines are characterized by systemic and contact action. The 
selectivity of their action is associated with the transformation of chlorine-substituted 
into the corresponding hydroxy-substituted compound, which is not toxic to cultivated 
plants. The mechanism of herbicidal action of most 1,3,5-triazine derivatives is based 
on inhibition of the Hill reaction and blocking of water photolysis. 
In the course of our research, we synthesized 6-nitroquinazolin-4-one (
1
) and 
reduced the nitro group with tin(II)-chloride dihydrate (SnCl
2
·2H
2
O) to obtain the 
corresponding 6-aminoquinazolin-4-one (