Organizing co mmittee

 
 
N
R
CO
2
Et
EtO
2
C
catalyst; )))
1-15 min
O
CO
2
Et
O
EtO
2
C
N
H
2
R
+

---

Poster presentation 
288 
1-(AMINOALKYL)ISOQUINOLINES AS CONVENIENT 
INTERMEDIATES FOR IMPORTANT HETEROCYCLIC 
PRODUCTS
 
 
S.M. Mirzokulov, A.B. Yusupov, D.B. Tukhtaev 
 
Samarkand state university, Samarkand 
e_mail: [e-mail] 
1-(Aminoalkyl)isoquinolines are known as important intermediates in the preparation 
of tricyclic and polycyclic heterocycles, in addition to being the end products of 
research. In particular, the manipulation of 1-(aminoalkyl)isoquinolines allows the 
formation of the imidazo[5,1-a]isoquinoline skeleton in convenient ways [1]. 1-
(aminoalkyl) isoquinolines can be converted into starting products for the synthesis of 
pyrazino [2,1-a] isoquinolines using the possibility of changing reagents and conditions 
[2]. Also, the specific strategy chosen may make this compound a good intermediate for 
the synthesis of benzo[
de
][1,7]naphthyridines.
Accordingly, 1-phthalimidomethyltetrahydroisoquinolines derived via N-phthaloyl-
α-amino acids [3] may be a convenient strategy for the synthesis of new saturated 1,7-
naphthyridines. Positive results of natural saturated 1,7-naphthyridine compounds 
against several types of cancer cells [4] give hope that such new structures are 
promising. 
References: 
1.
Tukhtaev D.B., Saidov A.S., Turgunov K.K., Vinogradova V.I., and 
Tashkhodzhaev B. Synthesis of N-Containing Heterocycles Based on α-Amino Acids. 
1. 8, 9-Dimethoxy-5, 6-Dihydro-3-Phenyl-1-Alkylimidazo [5,1-a] Isoquinolines 
//Chemistry of Natural Compounds. – 2019. – V. 55. – P. 1119-1122.
 
2.
Tang H., Zheng C., Lv J., Wu J., Li Y., Yang H., and Zhu J. Synthesis and 
antifungal activities in vitro of novel pyrazino [2,1-a] isoquinolin derivatives 
//Bioorganic and medicinal chemistry letters. – 2010. – V. 20. – №. 3. – P. 979-982.
 
3.
Tukhtaev D., Yusupov A., Vinogradova V. Synthesis of new Amides based on N-
Phthaloyl-α-Amino Acids //Egyptian Journal of Chemistry. – 2021. – V. 64. – №. 6. – 
P. 3049-3058.
 
4.
Wang F., Sun P., Sun Q. Bisleuconothine A protects periodontal tissue via the 
regulation of RANKL expression and infiltration of inflammatory cells //Tropical 
Journal of Pharmaceutical Research. – 2020. – V. 19. – №. 3. – P. 497-503.
 
N
NRR'
R''
and other
1,7-Naphthyridines
N
N
O
O
R
H
Benzo[
de
][1,7]naphthyridines
Pyrazino[2,1-
a
]isoquinolines
Imidazo[5,1-
a
]isoquinolines
1-(Aminoalkyl)isoquinolines
N
N
N
N
N
N
This work

---

Poster presentation 
289