Organizing co mmittee

EVALUATION OF THE EFFECT OF THE EXTRACT OBTAINED 
BY SAWING AND DRYING THE SEEDS OF TECHNICAL GRAPE 
VARIETIES ON THE PERFORMANCE
OF EXPERIMENTAL ANIMALS 
I.T. Abdinazarov, Z.I. Sanoev, S.D. Rakhimboev, S.Z. Rashidov,
T.T. Khamroev, A.I. Sanoev
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
To date, the antihypoxic activity of grape seed extracts is being studied based on 
studies of various grape varieties that exhibit a wide range of biological activity, 
including antioxidant, immunostimulating, anti-inflammatory, bactericidal, astringent 
and reparative. Also today, a number of scientific studies are being conducted on the 
basis of this plant to isolate new promising substances with high biological activity and 
conduct their pharmaco-toxicological studies.
In this regard, ICPS studied the effect of 
the extract obtained by sawing and drying the seeds of technical grape varieties on the 
performance of experimental animals in comparison with drugs used in medical 
practice.
All studies on the study of working capacity conducted on mongrel laboratory white 
mice with a body weight of 20-22 g and the effect of the studied substances on the 
performance of experimental animals was studied by the method of forced swimming 
with load. The average lethal dose for acute toxicity of the studied substance as a result 
of the LD
50
experiments with oral administration exceeds 18000 mg/kg and the 
substance belongs to class VI for acute toxicity and is considered absolutely non-toxic. 
Extract obtained by sawing and drying the seeds of technical grape varieties, was 
administered at doses of 10, 30 and 60 mg/kg, while the drug mildonat, as selected as a 
reference drug, had the greatest activity at a dose of 100 mg/kg and distilled water was 
orally administered to the control group in an amount equal to the volume of the test 
substance. In the conducted studies, grape seed extract in the studied doses increased the 
time of forced swimming of experimental animals close to those of Mildronat.
Thus, in the conducted studies it was found that the extract obtained by sawing and 
drying the seeds of technical grape varieties is absolutely non-toxic and harmless. At the 
same time, in studies, grape seed extract in the studied doses significantly increased the 
time of forced swimming of experimental animals and increased in slightly quantities at 
a higher dose compared with mildronate compared with control.

---

Poster presentation 
301