Organizing co mmittee

RESEARCH OF PSYCHOPHARMACOLOGICAL ACTIVITY OF 
1-(4-METHOXYPHENYL)-6,7-DIMETHOXY-1,2,3,4-
TETRAHYDROISOQUINOLINE 
 
Z.I. Sanoev, Yu.R. Mirzaev, Sh.N. Zhuraqulov, V.I. Vinogradova 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail]  
Scientists around the world are conducting experimental experiments on compounds 
derived from isoquinoline alkaloids in neurodegenerative diseases. Therefore, the 
synthesis of new compounds based on isoquinoline alkaloids is carried out in the 
laboratory of alkaloid chemistry of IСPS. In this regard, the alkaloid 1-(4-
methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline was synthesized and 
psychopharmacological studies were conducted. 
Materials and methods used for the study. Pharmacological studies were carried out 
on white mice weighing 18-24 g, stored in quarantine for 14 days in a vivarium. The 
effect of 1-(4-methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline on an 
attack caused by strychnine, corazole, catalepsy resulting from haloperidol, as well as 
anxiolytic activity by the Kilfoil method was studied. 
The obtained results and conclusions.
 
Anticonvulsant activity of the alkaloid 1-(4-
methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline was studied by injecting 
1.1 mg/kg of strychnine under the skin. The studied substance did not affect the latency 
period of seizures when administered orally at doses of 1 and 10 mg / kg, and the 
frequency of deaths decreased by 50%. Due to the excitation of the area of action of the 
cerebral hemispheres, pentylenetetrazole, which causes seizures, was administered 
subcutaneously at a dose of 70 mg/kg, and the substance under study was studied with 
oral administration at doses of 1 and 10 mg/kg. In this test, it can be seen that he 
increased the latency period by 1.5-2 times compared to the control group and reduced 
the frequency of deaths. Using a typical neuroleptic dose of haloperidol 0.3 mg/kg, the 
duration of catalepsy was observed for 6 hours. The test substance was administered 
orally at doses of 1 and 10 mg /kg, while a large dose with a catalepsy duration of up to 
4 hours in a small dose caused complete antagonism. Anxiolytic activity was observed 
by the Kilfoil
method for 2 minutes and at doses of 1 and 10 mg/kg showed 1.5 times 
higher activity compared to the control group. Thus, 1-(4-methoxyphenyl)-6,7-
dimethoxy-1,2,3,4-tetrahydroisoquinoline alkaloid showed a 2-fold reduction in the 
number of deaths due to the prevention of seizures caused by strychnine and corazole. It 
also has an effect against catalepsy arising from haloperidol, enhances dopamine-
positive activity and moderate anxiolytic activity.