Organizing co mmittee

TOTAL ECDYSTEROID-CONTAINING AND FLAVONOID-
CONTAINING SUBSTANCES FROM PLANTS OF UZBEKISTAN, 
THE POSSIBILITY OF THEIR PRACTICAL USE IN MEDICINE 
 
F.R. Egamova, S.M. Yusupova, V.N. Syrov 
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
Total ecdysteroid-containing substances from 
Ajuga turkestanica
(ecdysterone, 
turkesterone, cyasterone et al.), as well as total flavonoid-containing substances from 
Thermopsis alterniphlora
(apigenin, luteolin, formononetin et al.) and 
Pseudosophora 
alopecuroides
(glabrol, vexibidine, ammotamnidine et al.) were studied. That all these 
means in experimental conditions increase the adaptive potential of the body to the 
effects of adverse environmental factors. They have a pronounced positive effect on 
plastic and energy processes (mainly ecdysteroid-containing substances) and inhibit the 
development of lipid peroxidation processes (mainly flavonoid-containing substances). 
They exhibit an antistress effect, improve the tolerance of physical exertion, relieve 
fatigue, and exhibit pharmacotherapeutic effect when administered prophylactically to 
animals with experimental myocarditis, atherosclerosis, and CCl
4
-hepatitis. In separate 
series of experiments, an increase in the life expectancy of animals under subtotal 
irradiation was revealed under their influence, as well as the restoration of erythro- and 
leukopoiesis suppressed in this case. There is a restoration of the immunological 
reactivity of the body in secondary immunodeficiency states. 
The data obtained made it possible to test biologically active additives and drugs on 
the basis of these substances: exumide, ecditone, flaterone and flanorin in sports 
medicine and clinical practice as metabolically active agents that have a 
pharmacocorrective effect on many pre-pathological and pathological conditions of the 
organism. Ecdysteroid-containing drugs first of all proved promising in terms of 
improving the psycho-emotional status of athletes in various sports, improving their 
performance, eliminating asthenic and asthenodepressive symptoms during heavy 
physical exertion, whiter than easy adaptation to the conditions of stay. Under the 
influence of these funds, the process of rehabilitation of patients after severe somatic 
and surgical diseases is also accelerated. 
Flavonoid-containing drugs, along with a restorative effect on the body, have found 
wider use as therapeutic agents for hypercholesterolemia and atherosclerosis (flaterone), 
for some forms of liver damage: alcoholic and viral hepatitis, hepatocholecystitis 
(flanorin). 
The conducted work shows the prospects of searching for new effective medicines 
among phytoecdysteroids and flavonoids. 

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Oral presentation 
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