Organizing co mmittee

3,4
). 2,4-Symmetric disubstituted quinazolines (
5-8
) 
were synthesized from starting 2,4-dichloro-derivatives (
3,4
) by nucleophilic 
substitution 
reactions 
with 
secondary 
amines: 
3-methylpiperidine 
and 
4-
methylpiperidine: 
Experiments were conducted by heating mixture of 2,4-dichloroquinazolines (
3,4
) 
and piperidines in a 1:3 ratio in an absolute ethanol (80
°
C) for 6 hours, and 
corresponding compounds 
5-8
were synthesized. The structure of the obtained 
substances was confirmed based on the results of IR, 
1
H and 
13
C NMR-spectra. 
 
References 
4.
Verhaeghe P, Azas N, Gasquet M, Hutter S, Ducros C, Laget M, et al. Bioorganic 
& Medicinal Chemistry Letters. 2008; 
18
:396-401 
5.
Roopan SM, Maiyalagan T, Khan FN. Canadian Journal of Chemistry. 2008; 
86
:1019 
6.
Malamas MS, Millen J. Journal of Medicinal Chemistry. 1991; 
34
:1492-1503.

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Poster presentation 
258 
REACTION OF N-(5-AMINO-1H-BENZO[d]IMIDAZOL-2-YL) 
ACETAMIDE WITH CARBOXYLIC ACIDS 
Sh.X. Kubayev, S.S. Saidov, R.K. Karimov, A.Sh. Abdurazakov, B.J. Elmuradov 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
Over the past 30 years, the chemical industry in our country has been radically 
reformed in accordance with modern requirements, and the volume of output of 
chemical enterprises has increased several times. Due to the wide range of biological 
activity, nitrogen-containing heterocyclic compounds are at the forefront in terms of 
production volume among other organic compounds. In this regard, a special place is 
occupied by 2-aminobenzimidazole (2-AB) and its derivatives. The importance is the 
scientific research aimed at obtaining new products, the search for biologically active 
substances among the compounds obtained [1]. 
To further expand of synthesis analogues of N-(5-amino-1H-benzo[d]imidazol-2-yl) 
acetamide, the acylation reaction was carried out with various aliphatic carboxylic 
acids, such as propionic, butyric, isobutyric acids under identical conditions with glacial 
acetic acid. 
In the continuation of research in this direction, the acylation of N-(5-amino-1H-
benzo[d]imidazol-2-yl)acetamide with aromatic carboxylic acids was studied. The 
reaction was carried out at an equimolar ratio of reagents, the reaction was carried out at 
the boiling point of acids, for 2 hours. 
It is determined that in this case takes place acylation of 5-NH2 group and structure 
of the synthesized compounds is confirmed by modern physicochemical methods IR, 
1H, NMR, 13C NMR spectroscopy, mass spectrometry. 
Reference 
1. A.Sh. Abdurazakov, S.S. Saidov, R.Ya. Okmanov, Sh.Kh. Kubaev, B.Zh. 
Elmuradov. Alternative and efficient method for the preparation of 2-
acetamidobenzimidazoles. Egypt. J. Chem. 2021, Vol. 64, No. 5 pp. 2247 – 2252. 

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Poster presentation 
259