SYNTHESIS OF PHARMACOLOGICALLY ACTIVE ISOQUINOLINE DERIVATIVES Z.E. Urunbayeva, S. Usarova, A.Sh Saidov. Sh. Samarkand State University named after Rashidov In recent years, the synthesis of isoquinoline derivatives has aroused great interest in
synthetic chemists and directed their scientific research to the development of the
synthesis of such structural substances, and establishing their structure using modern
physicochemical methods and determining their chemical and biological properties is
one of the urgent issues.
As a continuation of our previous work, we conducted the second-stage amylation
reaction thermally by heating carbonic acid and homoveratrylamine in an oil bath at
178°C for 2-4 hours, and as a result of amidation, amide and diamide derivatives were
synthesized. The cyclization stage was carried out by adding POCl
3
to the acid amide
according to the method of the Bishler-Napiralsky reaction, heating for 4-6 hours with a
reverse cooler, and 3,4-dihydroisoquinoline derivatives were synthesized.
3 H
3
CO
H
3
CO
HN
C
O
CH
2
C
C
CH
2
O
NH
OCH
3
OCH
3
+
HOOC CH
2
C COOH
CH
2
ClOC CH
2
C COCl
CH
2
1 NH
2
H
3
CO
H
3
CO
t
o
2
5
6
2
''
3
''
4
''
2
'
5
'
6
'
C
NH
OCH
3
OCH
3
O
H
3
CO
H
3
CO
N
O
PCl
5
2 6 5
