Organizing co mmittee

 
 

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Poster presentation 
303 
PECULIARITIES OF THE PSYCHOTROPIC ACTIVITY
OF DONSUMIN 
 
Yu.R.
 
Mirzaev
1
, E.M. Ruzimov, S.F. Aripova
1
, I.Zh.
.
Zhalolov
2
, R.A.
 
Botirov
1
 
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
 
2) Ferghana State University, Ferghana 
It has been established that donsumin, the sum of four indole alkaloids of the 
tryptamine series from the aboveground parts of Arundo Donax, is a blocker of 5HTA
2
D receptors. The alkaloid at a dose of 1 and 10 mg/kg increased motor activity by 12 
and 280% (MA) and increased verticalization from phenamine. At a dose of 30-50 
mg/kg, activation alternated with periods of sedation, 100 mg/ kg caused a sedative 
effect. From a dose of 500 mg / kg, mice calmed down and muscle weakness was noted, 
after 10 minutes. the weakness increased, the mouse was only able to crawl. When 
hanging by the tail, there was a slight tremor and twitching. After 2 hours, 1 mouse fall 
down of 6 fell. LD
50
was 1030 mg/kg orally. At a dose of 10 mg/kg accelerated the 
production of conditioned reflex of passive avoidance (CFPA) and accelerated the 
search activity for C. Hall. With 45-day daily administration on all days, MA increased 
from 70 to 280% compared to the control ones. After 2 days the cancellation of 
Donsumin, the MA in the experimental and control groups was the same. A dose of 10 
inhibited haloperidol catalepsy, and 100 mg/kg had no effect. At a dose of 10 mg/kg, 
mutual antagonism of dopamine and haloperidol 0.3 mg/kg was noted, at a dose of 100 
mg/kg, search activity and antagonism to haloperidol catalepsy were completely 
eliminated.
The strengthening of MA and stereotypes of verticalization from phenamine, the 
acceleration of CFPA and search activity, antagonism to haloperidol catalepsy – 
indicate that Donsumin belongs to psychostimulants. When comparing Donsumin and 
phenamine, it was found that the minimum MA activating doses corresponded to 1 
orally and 0.3 mg/kg s/c with acute toxicity – 1030 orally and 28 mg/kg s/c, which 
indicates the multiple superiority of the pharmacological latitude of the first over the 
second. Phenamine dose-dependent stimulates the central nervous system and the death 
of animals occurs from toxic phenomena from the cardiovascular system. In Donsumin, 
the activation of the central nervous system begins with a dose of 1 mg/kg, the optimal 
is 10 mg/kg and the maximum "therapeutic" is 30 mg/kg. A dose of 100 mg/kg and 
above, Donsumin exhibits sedative and neuroleptic effects.
Thus, if phenamine is a representative of typical psychostimulants, then Donsumin 
can be attributed to atypical, showing the main psychostimulating properties in the 
range of 1-30 mg/kg. Death occurs against the background of adenamia and respiratory 
arrest.