SYNTHESIS SELENIUM NANOPARTICLES IN SOLUTION SODIUM - CARBOXYMETHYLCELLULOSE BASED ON NANOCOMPOSITES FOR THE CANCER TREATMENT Foziljon Turakulov, Khaydar Yunusov, Abdushkur Sarymsakov Institute of Chemistry of Polymer Physics, Uzbekistan Academy of Sciences. 100128, Tashkent, str. A. Khodiry, 7 “b” . e-mail: polymer@academy.uz Selenium nanoparticles are well known for their antitumor properties and have been
successfully used in medicine for the treatment of cancer diseases. Selenium
nanoparticles are also one of the essential elements for humans and It has been
confirmed that selenium can improve the activity of the seleno-enzyme, glutathione
peroxidase and prevent free radicals from damaging cells and tissues in vivo.
The purpose of this work is to study the possibilities of synthesis of stabilized
selenium nanoparticles (SeNPs) in the solution of sodium-carboxymethcellulose (Na-
CMC) based on composites and to study their physicochemical properties.
In this study, aqueous solutions of sodium selenite (Na
2
SeO
3
) with a concentration of
0.01 M were used to synthesize SeNPs from selenite ions (SeO
3
2-
). Purified Na-CMC
samples with a degree of polymerization (DP) 1015 and degree of substitution (DS)
0,85 were selected as the stabilizing polymer matrix. In the presence of ascorbic acid
(C
6
H
8
O
6
) in a 2% aqueous solution of the selected purified Na-CMC, SeO
3
2-
of
Na
2
SeO
3
salt are reduced to zero-valent (0) selenium element and SeNPs are formed in
the solution (reaction 1).
Na 2 SeO 3 + 2C 6 H 8 О 6
