1b and
1c ,
demonstrating high inhibitory activity not only against Gram-positive bacteria
but filamentous fungi that can, among other things, damage works of art, such as
tempera painting. In this case the fungal growth inhibitory concentration appears to be
in the range of 0.5 - 3 mM. The replacement of the 3′-hydroxyl group with amino,
aminoethyl and dialkylamino groups significantly enhances the antifungal activity, most
prominently towards
Aspergillus genus. Several new compounds were able to
completely inhibit growth of all the tested moulds (at 0.7 mM), previously isolated in
the Moscow State Tretyakov Gallery. In particular, such compounds are promising for
use as antiseptics for protecting works of art from mould fungi.
3′-Modified N
4
-alkyl-5-methyl-2′,3′-dideoxycytidines
4 also demonstrate activity
against gram-positive bacteria as well as mycobacteria.
Unfortunately, their high
cytotoxicity does not allow to consider them as potential antibacterial drugs. However,
cytotoxicity is not the issue for their application on lifeless but (hopefully) eternal works
of art. It appeared that our compounds display a wide range of activity against a large
number of microorganisms. In this regard, the obtained substances may be an important
tool for preventive treatment and scientific restoration of tempera paintings and oil
paintings on canvas as biocidal coatings.
REFERENCE
: 1.
Alexandrova et al, Eur. J. Med. Chem., 2021, 215; 2). Alexandrova et al,
New Journal of Chemistry , 2022,
46 , 5614
Poster presentation
41
QUANTITATIVE ANALYSIS OF FLAVONOIDS OF THE LEAVES OF LINGONBERRY (FOLIUM VITIS IDAEAE),
