Organizing co mmittee

 
References: 
1. S. Yerzhepov, Flora of Kara-Kalpak, its economic description, use and guard. – 
Tashkent: Fan, 1978. P. 22–24. 
2. J. Wang, H. Liu, H.Gao, J. Zhao, L. Zhou, J. Han, Z. Yu and F. Yang, Natural 
Product Communications, 6 (11). 1749 (2011) 
3. J. Wang, J. Lou, Chao Luo, L. Zhou, M. Wang and .L. Wang, Int. J. Mol. Sci., 13, 
11349 (2012) 
4. G.Zh. Baisalova, G. Ozek, K.H.C. Baser, S.B. Rakhmadieva, Pharmacognosy 
Magazine, 6 (22). 127. (2010) 

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Poster presentation 
80 
GC-MS ANALYSIS AND COMPARISION ON
Haplophyllum pedicellatum 
 
Kh. A. Rasulova
1
, M. A. Eshonov
,2
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent. 
[e-mail] 
2) National University of Uzbekistan named after Mirzo Uluqbek, 100174, Tashkent, 
University street 4, phone [phone]
. e-mail: [e-mail]
 
 
The genus 
Haplophyllum
belongs to 
Rutaceae 
family, comprising of approximately 
50 species, which is widely distributed in the Central Asia, Southern Europe, the 
Mediterranean coast and northwest and northeast of China. The genus plants have been 
used in folk medicine for the treatment of burns, toothache, stomach, respiratory organs 
and skin diseases, and several types of cancer. 
A decoction of leaves of 
Haplophyllum pedicellatum
Bge. Is widely used in folk 
medicine at toothache, stomach diseases, meteorism, external in itch. 
For the first time we studied alkaloids of the overground part of 
Haplophyllum 
pedicellatum
from a new growing place. The aerial part in flowering period containe 
0.29% of alkaloids. By separation of the total alkaloids the following alkaloid were 
isolated: γ-fagarine, skimmianine, haplamine, glicoperine, haplotusine, robustine, 
perfamine, folifine, folipidine and new quinolin-2-one alkaloids - pedicine, pedilinine. 
By GC-MS analysis, the major components in petroleum ether fraction of the plant 
H. pedicellatum,
collected from Babatag, Surhandarya were identified and main 
components from the aerial part were Alloaromadendrene - 25.11 min (2.04%), 1,3-
dihidroxy-
dl
-glyceradehyde dimer - 27.43 min (0.9%), 
L
-β-Seseline (8,8-dimethyl-2H, 
8H-pyrano[2, 3-f]chromen-2-one) - 2.74 min (28.31 %), Junipene – 2.74 min (28.31%), 
Patchoulene – 3.30 min (31.94%), Eudesma-3,11-diene – 3.30 min (31.94%), 
Hexadecane – 37.57 min (49.64 %), Linolenic acid (11.99 %). In petroleum ether 
fraction of flowers, major components were 5 (4H)-Isoxazolone, 3-phenyl-4-
(phenylmethy- (38.95%), Seselin (2H, 8H-Benzo [1, 2-b: 3, 4-b'] dipyran-2-one, 8,8-
dimethyl) (28.96 %). Main components of the extracts of the plant from Kashkadarya 
(petroleum ether fraction) were Dodecanoic acid (20.47%), Tetradecanoic acid 
(19.60%), 
n
-Hexadecanoic acid (10.08%), Phytol (8.24%), 15-Octadecatrienoic acid, 
methyl ester (15.28%), 9,12-Octadecadienoic acid, methyl ester, (
E
,
E
)- (11.88%), 9-
Octadecenoic acid (
Z
)-, and methyl ester (11.02%).

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Poster presentation 
81